Results 101 to 110 of about 6,825,361 (206)

TET Family Proteins and Their Role in Stem Cell Differentiation and Transformation

, 2011
One of the main regulators of gene expression during embryogenesis and stem cell differentiation is DNA methylation. The recent identification of hydroxymethylcytosine (5hmC) as a novel epigenetic mark sparked an intense effort to characterize its ...
Omar Abdel-Wahab, Ross L. Levine, Luisa Cimmino, Iannis Aifantis, Cimmino, Luisa, Abdel-Wahab, Omar, Levine, Ross L., Aifantis, Iannis   +7 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

miRNA-Based Therapies in B Cell Non-Hodgkin Lymphoma.

, 2020
Non-Hodgkin lymphoma (NHL) is a diverse class of hematological cancers, many of which arise from germinal center (GC)-experienced B cells. Thus GCs, the sites of antibody affinity maturation triggered during immune responses, also provide an environment ...
Yébenes, Fuertes, Teresa, Ramiro, Almudena R, García-Yébenes Mena, Virginia Pilar   +3 more
core   +1 more source

Familija Bcl 2 proteina kod malignih bolesti [PDF]

Vojnosanitetski Pregled, 2004
Brajušković Goran R., Milić-Škaro Anđelija, Cerović Snežana J., Marjanović Slobodan A., Ušaj-Knežević Slavica, Čizmić Milica, Dimitrijević Jovan   +6 more
doaj   +1 more source

La relación núcleo-citoplasmática en la diferenciación y transformación celular del epitelio mamario

Revista Chilena de Obstetricia y Ginecología, 2012
Antecedentes: Las células pertenecientes a la línea HC11 son estimuladas tanto a proliferar mediante el Factor de Crecimiento Epidérmico, como a diferenciar estimuladas con dexametasona, insulina y prolactina, dando origen a los tipos celulares HC11 GM y
Ricardo Cornejo U
doaj  

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Nuclear and cytosolic fractions of SOX2 synergize as transcriptional and translational co-regulators of cell fate.

Stemness and pluripotency are mediated by transcriptional master regulators that promote self-renewal and repress cell differentiation, among which is the high-mobility group (HMG) box transcription factor SOX2. Dysregulated SOX2 expression, by contrast,
Zavolan, Mihaela, Wymann, Matthias P, Roffeis, Sarah, Zmajkovic, Jakub, Tintignac, Lionel, Ataman, Meric, Mittal, Nitish, Bock, Thomas, Velychko, Sergiy, Börsch, Anastasiya, Hess, Christoph, Wang, Hui, Candido, Silvia, Tata, Nageswara Rao, Schaefer, Thorsten, Jacob, Francis, Skoda, Radek C, Lengerke, Claudia, Baßler, Jochen, Hurt, Ed, Dumlin, Alain, Löliger, Jordan, Zaehres, Holm, Schöler, Hans R, Schürch, Christoph, Lötscher, Jonas, Schmidt, Alexander   +26 more
core   +1 more source

Peripheral Blood T‐Cell Receptor Repertoire Diversity as a Potential Biomarker in the Diagnosis and Treatment Evaluation of Colorectal and Lung Cancers: A Prospective Observational Study

Cancer Medicine
Background T‐cell receptor (TCR) diversity 50 (D50) values could assess peripheral blood (PB) TCR diversity and immunity. This study aimed to evaluate the potential D50 value in the diagnosis and treatment evaluation of colorectal cancer (CRC) and ...
Jilong Ma, Yuanbiao Wang, Zhixin Zhang, Xinyi Cai, Xudong Xiang, Yan Chen, Fengqiong Sun, Jian Dong   +7 more
doaj   +1 more source

Proteomic analysis reveals LRPAP1 as a key player in the micropapillary pattern metastasis of lung adenocarcinoma

Heliyon
Objectives: Lung adenocarcinomas have different prognoses depending on their histological growth patterns. Micropapillary growth within lung adenocarcinoma, particularly metastasis, is related to dismal prognostic outcome. Metastasis accounts for a major
Hao-jie Yan, Sheng-cheng Lin, Shao-hang Xu, Yu-biao Gao, Bao-jin Zhou, Ruo Zhou, Fu-ming Chen, Fu-rong Li   +7 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source