Results 81 to 90 of about 6,825,361 (206)

p57(Kip2) imposes the reserve stem cell state of gastric chief cells

, 2022
Adult stem cells constantly react to local changes to ensure tissue homeostasis. In the main body of the stomach, chief cells produce digestive enzymes; however, upon injury, they undergo rapid proliferation for prompt tissue regeneration.
Ju, Young Seok, Caldwell, Brianna, Wu, Szu-Hsien Sam, Choi, Eunyoung, Stange, Daniel E., Park, JinYoung, Bamford, Aileen-Diane, Kim, Somi, Kim, Jihoon, An, Yohan, Bon-kyoung Koo, Kim, Jong Kyoung, Rocha, Andreia Sofia Batista, Pilat-Carotta, Sandra, Josserand, Manon, Lee, Heetak, Han, Seungmin, Lee, Ji-Hyun, Philpott, Anna, Fink, Juergen, Szep-Bakonyi, Réka, Min, Jimin, Koo, Bon-Kyoung, Lee, Sieun, Simons, Benjamin D., Aileen-Diane Bamford, Heetak Lee, Sandra Pilat-Carotta, Réka Szep-Bakonyi, Somi Kim, Jimin Min, Szu-Hsien Sam Wu, Juergen Fink, JinYoung Park, Seungmin Han, Eunyoung Choi, Jong Kyoung Kim, Andreia Sofia Batista Rocha, Anna Philpott, Ji-Hyun Lee, Daniel E. Stange, Benjamin D. Simons, Sieun Lee, Brianna Caldwell, Yohan An, Jihoon Kim, Young Seok Ju, Manon Josserand   +47 more
core   +1 more source

Regeneration and plastid transformation approaches in Arabidopsis thaliana and Rapid-Cycling Brassica rapa [PDF]

, 2011
Plastid transformation is a well-established tool for biotechnology as it allows highexpression levels of proteins and as it provides biological transgene containment because of maternal inheritance of cytoplasmic genes in most crops.
Herrera Díaz, Areli
core   +1 more source

Squamous cell transformation as a mechanism of acquired resistance to tyrosine kinase inhibitor in EGFR‐mutated lung adenocarcinoma: a report of two cases

Respirology Case Reports, 2020
Pathological transformation to squamous cell carcinoma after epidermal growth factor receptor (EGFR)‐tyrosine kinase inhibitor treatment has been reported, but details of the transformation remain unclear.
Hironori Uruga, Takeshi Fujii, Nobuyuki Nakamura, Shuhei Moriguchi, Kazuma Kishi, Hisashi Takaya   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Genetic Alterations Impact Immune Microenvironment Interactions in Follicular Lymphoma.

, 2020
Interactions between germinal center B cells and immune cells in the microenvironment can play integral roles in transformation and growth of follicular lymphoma (FL).
Riether, Carsten, Ochsenbein, Adrian
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

SWI/SNF Complex Prevents Lineage Reversion and Induces Temporal Patterning in Neural Stem Cells [PDF]

, 2014
Members of the SWI/SNF chromatin-remodeling complex are among the most frequently mutated genes in human cancer, but how they suppress tumorigenesis is currently unclear.
Knoblich, Juergen A., Reichert, Heinrich, Burkard, Thomas R., Saini, Nidhi, Eroglu, Elif, Homem, Catarina C. F., Jiang, Yanrui, Knoblich JA, Burkard, TR, Homem, CCF, Saini N, Jiang, Y, Homem CCF, Burkard TR, Knoblich, JA, Eroglu E, Saini, N, Jiang Y, Reichert H, Eroglu, E, Reichert, H   +20 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Transformation of Lung Squamous Cell Carcinoma to Small Cell Lung Cancer After Immunotherapy Resistance: A Case Report

Cancer Management and Research, 2023
Diming Wang,1,* Wei Ye,2,* Dongmei Chen,1 Qingming Shi,1 Dongchun Ma3 1Department of Oncology, Anhui Chest Hospital, Hefei, 230022, People’s Republic of China; 2Department of Pathology, Anhui Chest Hospital, Hefei, 230022, People’s Republic of ...
Wang D, Ye W, Chen D, Shi Q, Ma D
doaj  

Autoimmune hepatitis with giant-cell transformation

Annals of Hepatology, 2009
Background/Aims: Giant-cell hepatitis (GCH), also known as postinfantile or syncytial giant cell hepatitis, is a frequent pattern of liver injury in the neonate, primarily seen in the first three months of life.
José Estradas, Virginia Pascual-Ramos, Braulio Martínez, Misael Uribe, Aldo Torre, MD., M.Sc.   +4 more
doaj   +1 more source