Results 91 to 100 of about 6,825,361 (206)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Transformation from Small Cell to Squamous Cell Carcinoma in a Thymic Carcinoma Patient with a Durable Response to Anlotinib: A Case Report

Cancer Management and Research, 2022
Wenru Qin,1,2,* Bing Zou,2,* Xinyu Fan,2,3 Bingjie Fan,2 Shijiang Wang,2 Linlin Wang2 1Department of Oncology, Weifang Medical University, Weifang, Shandong, People’s Republic of China; 2Department of Radiation Oncology, Shandong Cancer Hospital ...
Qin W, Zou B, Fan X, Fan B, Wang S, Wang L   +5 more
doaj  

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Cancer Cell of Origin: Spotlight on Luminal Progenitors [PDF]

, 2010
Does basal type breast cancer arise from oncogenic transformation of a basal cell type? In this issue of Cell Stem Cell, Molyneux et al. (2010) investigate the provenance of the basal-type BRCA1 breast carcinoma and come up with unanticipated ...
Christine L. Chaffer, Robert A. Weinberg, Chaffer, Christine L., Weinberg, Robert A   +3 more
core   +1 more source

Maternal circadian disruption during pregnancy and offspring diabetic cardiovascular disease risk

Frontiers in Cell and Developmental Biology
Circadian rhythm disruption during pregnancy has been recognized as a growing public health concern, affecting approximately 20% of the workforce due to shift work and prevalent lifestyle-related factors.
Saman Saedi, Saman Saedi, Hailong Bing, Jiaxing Wu, Jiaxing Wu, Yaoxin Gao, Yaoxin Gao, Chunyan Wang, Qinjun Chu, Zhengyuan Xia, Zhengyuan Xia, Zhengyuan Xia   +11 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Chrysoeriol Alleviates Psoriasis Inflammation and Keratinocyte Hyperproliferation Possibly Through Inhibiting AKT/NF-κB Signaling Activation

Journal of Inflammation Research
Xiaoyue Qi,1,* Luoming Zhang,2,* Yaoxin Gao,2 Shoukui Hu,3 Yiming Shao,2 Xiaoyan Jia,2 Shujuan Zhang,3 Baodong Ma21School of Life Sciences, Zhengzhou University, Zhengzhou, 450052, People’s Republic of China; 2Cell Research and ...
Qi X, Zhang L, Gao Y, Hu S, Shao Y, Jia X, Zhang S, Ma B   +7 more
doaj  

Development and efficacy validation of a T3cDM risk model for pancreatitis patients based on multivariate logistic regression—with a dynamic prediction tool

European Journal of Medical Research
Background Type 3c diabetes mellitus (T3cDM) is increasingly recognized with the rising incidence of pancreatitis, yet its risk profile and early diagnostic tools remain insufficient.
Xiaoyan Jia, Xin Li, Ruijia Lian, Baodong Ma, Xiwen Ma   +4 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source