Results 191 to 200 of about 521,452 (268)

Case Report: Autologous stem cell transplantation in a patient diagnosed with AL amyloidosis in Kazakhstan. [PDF]

Front Oncol
Kolesnikova O, Kemaykin V, Burkitbayev Z, Karabekov A, Kolesnev A, Ainabay A, Ruzal V, Yusupova M, Shokubaeva F, Tursyn A, Kuanysh Z.   +10 more
europepmc   +1 more source

NUDT21 Drives T‐Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation

Advanced Science, EarlyView.
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu, Jianwei Wang, Zhiheng Li, Qi Ji, Hui Zhang, Qinyi Zhang, Senlin Zhang, Juanjuan Yu, Yanfang Tao, Yijun Wu, Chunxia Shi, Zong Zai, Zimu Zhang, Yizhen Li, Zhenjiang Bai, Shaoyan Hu, Jian Pan, Yang Yang, Shuiyan Wu   +18 more
wiley   +1 more source

Nurses' perspectives on caregiver engagement in hematopoietic stem cell transplantation: A qualitative study. [PDF]

Support Care Cancer
Ersoy NA, Atakul E, Akyar I.
europepmc   +1 more source

Cancer‐Associated Fibroblasts Promote Tumor Immunosuppression in Hepatocellular Carcinoma via the NNMT‐ANGPTL4 Axis

Advanced Science, EarlyView.
ABSTRACT Background & Aims: Cancer‐associated fibroblasts (CAFs) drive immunosuppression in hepatocellular carcinoma (HCC). However, their metabolic regulation remains poorly defined. We investigated the role of nicotinamide N‐methyltransferase (NNMT) in CAFs. Approach & Results: High NNMT expression in CAF tissues was confirmed by western blotting and
Shounan Lu, Shanjia Ke, Hongjun Yu, Zhanzhi Meng, Miaoyu Bai, Yanan Xu, Hui Zhu, Jinwen Yang, Baolin Qian, Bing Yin, Chaoqun Wang, Zhigang Feng, Zhongyu Li, Yongzhi Zhou, Zihao Li, Xinglong Li, Yongliang Hua, Yao Fu, Wei Tang, Yaohua Wu, Yong Ma   +20 more
wiley   +1 more source

Decision-Making in Pediatric Hematopoietic Stem Cell Transplantation: Perspectives of Physicians, Patients, and Families. [PDF]

Cureus
Arenas-Pérez L, Calderon A AF, Estrada D.   +2 more
europepmc   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Hemopoietic stem cell transplantation for infectious mononucleosis-related aplastic anemia. [PDF]

Ann Hematol
Cordella S, Gilioli A, Pioli V, Messerotti A, Forghieri F, Bettelli F, Morselli M, Cassanelli L, Potenza L, Marasca R, Bresciani P, Cuoghi A, Luppi M.   +12 more
europepmc   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Impact of allogeneic stem cell transplantation in patients with higher risk myelodysplastic syndromes. [PDF]

Blood Cancer J
Bazinet A, Bataller A, Chien K, Sasaki K, Montalban-Bravo G, Hammond D, Bouligny I, Swaminathan M, Jen WY, Kugler E, Kanagal-Shamanna R, Kadia T, Borthakur G, DiNardo C, Short N, Pemmaraju N, Jabbour E, Daver N, Ravandi F, Urrutia S, Gener-Ricos G, Braish J, Briski R, Rodriguez-Sevilla JJ, Li Z, Champlin RE, Shpall EJ, Alousi A, Oran B, Hosing C, Ramdial JL, Olson A, Pierce S, Chen J, Kantarjian H, Garcia-Manero G, Popat U.   +36 more
europepmc   +1 more source

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source