Results 281 to 290 of about 1,038,668 (364)

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

Haploidentical Hematopoietic Stem Cell Transplantation With Anti-Thymocyte Globulin in the Treatment of Older Adults With Hematological Malignancy. [PDF]

EJHaem
Kong X, Han J, Liu Y, Song B, Tang X, Xue S, Miao M, Han Y, Wang Y, Chen S, Sun A, Hu M, Chen J, Chen F, Zhang J, Qiu HY, Wu D.   +16 more
europepmc   +1 more source

Cell migration, chimerism, and graft acceptance: A new view of organ transplantation [PDF]

, 1994
Cillo, U, Demetris, AJ, Murase, N, Ricordi, C, Starzl, TE, Trucco, M   +5 more
core  

KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling

Advanced Science, EarlyView.
This study aims to evaluate the impact of the potassium channel KCNJ2 on asthma development. KCNJ2 promotes NLRP3 inflammasome activation through both Ca2+ influx and K+ efflux in airway epithelial cells, which drives allergic airway inflammation and remodeling, suggesting a promising therapeutic target for asthma.
Yachao Cui, Shumei Wu, Yang Peng, Yiqi Liu, Li Che, Shiying Chen, Feng Zhang, Dajiang Qin, Shiyue Li, Pixin Ran, Wenguang Yin   +10 more
wiley   +1 more source

Targeting Aurora kinase A to prevent GVHD and relapse after myeloablative allogeneic hematopoietic cell transplantation. [PDF]

Blood Adv
Holtan SG, Grover P, Walton K, El Jurdi N, Quinones V, Maakaron JE, Juckett MB, Bachanova V, Hou JH, Terezakis S, Myers TJ, Paradiso LJ, DeFor TE, Cao Q, Betts BC.   +14 more
europepmc   +1 more source

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

International Survey for Antiemetics in Hematopoietic Stem Cell Transplantation in the APBMT Centers. [PDF]

Blood Cell Ther
Yakushijin K, Perram J, Ho A, Farzana T, Iida H, Lee JW, Inamoto Y, George B, Wu D, Suzuki R, Behfar M, Huang H, Asawapanumas T, Rowlings P, Poudyal BS, Santosa D, Gyi AA, Altangerel O, Wanitpongpun C, Gan GG, Iyama S, Iqbal S, Ramzi M, Khadwal A, Kato J, Sim J, Cheng J, Ma D, Chua YX, Okamoto S, Iida M, Fuji S.   +31 more
europepmc   +1 more source

Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration

Advanced Science, EarlyView.
Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman, Carla Alvarez Rivas, Aashish Srivastava, Nora Marek, Kamal Mustafa, Alpdogan Kantarci   +5 more
wiley   +1 more source

Allogeneic hematopoietic stem cell transplantation for the treatment of chronic active Epstein-Barr virus infection. [PDF]

Cell Transplant
Wang Y, Wu J, Huang X, Xiao Y.
europepmc   +1 more source

Cell migration, chimerism, and graft acceptance: with particular reference to the liver [PDF]

, 1996
Demetris, AJ, Murase, N, Ricordi, C, Starzl, TE, Trucco, M   +4 more
core