Results 121 to 130 of about 341,348 (303)

Synergistic exacerbation of oral mucositis caused by IL-23 deficiency and oral Candida albicans exposure

mBio
Targeted head and neck irradiation (HNI) used for cancer therapy causes mucosal damage and immune dysregulation, leaving cancer patients highly susceptible to infections of the oral mucosa.
John T. Dillon, Maura T. Hickey, Jessica Saul-McBeth, Trevor Glanz, Yusuf Daboul, Yashwanth R. Byreddy, Raymond Hohl, Jacqueline M. Kratch, Jia A. Thakker, Sarah L. Gaffen, Jacob Gibbs, Heather R. Conti   +11 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Epithelial polarity and growth signaling by Drosophila tumor suppressor genes

, 2018
The Drosophila model system has been at the forefront of many scientific discoveries. Studies of tumor suppressor genes in fruit flies have provided major insights towards polarity and growth signaling, while also aiding the understanding of complex ...
Vreede, G., Sub Developmental Biology
core  

TONSOKU prevents the formation of large tandem duplications and restrains ATR–WEE1 checkpoint activation

Nature Communications
Copy number variation (CNV) plays a fundamental role in modulating plant agronomic traits and tumorigenesis in animals. While frequently linked to replication stress, the mechanisms giving rise to CNVs are not fully elucidated.
Geoffrey Thomson, Axel Poulet, Yi-Chun Huang, Hong-Sheng Liao, Chantal LeBlanc, Yannick Jacob   +5 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Taking a Developmental Perspective on Systems Biology

, 2011
Developmental biologists understand how different cells contribute to organ function and how cellular components work together to produce a phenotype. These insights need to be more widely applied to systems biology.
Philip N. Benfey, Benfey, Philip N.
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Frontiers in Cell and Developmental Biology, Genetics, Nutrition and Physiology

Lipidology is a specialty section of Frontiers in Cell and Developmental Biology, Frontiers in Genetics, Frontiers in Physiology and Frontiers in Nutrition.
RODRIGUEZ ESTRADA, MARIA TERESA
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Xenopus laevis – model organism in developmental biology [PDF]

, 2016
Xenopus laevis, afrička pandžašica, je vodozemac koji živi u slatkim vodama. Postao je modelni organizam za kralježnjake u razvojnoj biologiji zahvaljujući visokom stupnju konzerviranosti vlastitih esencijalnih staničnih i molekularnih mehanizama, kao i ...
Batović, Margarita
core