Results 111 to 120 of about 333,412 (259)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Genetic perspectives on the ascidian central nervous system

Invertebrate Survival Journal, 2009
In 2002, date of publication of the Ciona intestinalis genome, ascidians entered the post-genomic era. This tool had a fundamental role and has become the starting point for a series of new functional and genomic studies.
A Locascio, F Ristoratore, A Spagnuolo, L Zanetti, M Branno   +4 more
doaj  

Mapping the cellular basis of species differences in oxytocin and dopamine receptor expression in the vole nucleus accumbens

Scientific Reports
Oxytocin (Oxtr) and dopamine (Drd1, Drd2) receptors provide a canonical example for how differences in neuromodulatory receptors drive individual and species-level behavioral variation. These systems exhibit striking and functionally relevant differences
Meredith K. Loth, Julia C. Schmidt, Cassandra A. Gonzalez, Liza E. Brusman, Julie M. Sadino, Kelly E. Winther, David S. W. Protter, Zoe R. Donaldson   +7 more
doaj   +1 more source

Single-Cell Omics in Animal Reproductive Biology: A Cellular and Molecular Atlas Across Developmental Stages

Insights in Animal Science
The cutting-edge technologies of single-cell omics have revolutionized the study of animal reproduction, enabling the visualization of cellular and molecular domains in organisms during various growth stages. This review presents a conceptual framework grounded in the latest developments from single-cell RNA sequencing (scRNA-seq), ATAC sequencing ...
Kamran Ahmad Nasir, null Sohaib Khan, null Hassan Abbas, null Kashif Raza Zaidi   +3 more
openaire   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

A perspective on molecular and cellular biology-based developmental toxicology biomarkers

BIOCELL, 2023
SUKHENDU DEY, SANDIPAN PAL, APURBA RATAN GHOSH, PALAS SAMANTA   +3 more
openaire   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

An experimental framework to assess biomolecular condensates in bacteria

Nature Communications
High-resolution imaging of biomolecular condensates in living cells is essential for correlating their properties to those observed through in vitro assays. However, such experiments are limited in bacteria due to resolution limitations.
Y Hoang, Christopher A. Azaldegui, Rachel E. Dow, Maria Ghalmi, Julie S. Biteen, Anthony G. Vecchiarelli   +5 more
doaj   +1 more source