Results 111 to 120 of about 358,177 (298)

Developmental phase transitions in Norway spruce [PDF]

, 2013
Plant development proceeds through distinct phases that are controlled by complex networks of regulatory genetic circuits and fine-tuned by environmental and endogenous cues.
Uddenberg, Daniel
core   +1 more source

Developmental, Cellular and Molecular Biology of Benign Prostatic Hyperplasia [PDF]

Differentiation, 2011
William A, Ricke, Jill A, Macoska, Gerald R, Cunha   +2 more
openaire   +2 more sources

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Frontiers in Cell and Developmental Biology, Genetics, Nutrition and Physiology

Lipidology is a specialty section of Frontiers in Cell and Developmental Biology, Frontiers in Genetics, Frontiers in Physiology and Frontiers in Nutrition.
RODRIGUEZ ESTRADA, MARIA TERESA
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

FATE-MAP predicts teratogenicity and human gastrulation failure modes by integrating deep learning and mechanistic modeling

Nature Communications
Gastrulation, a critical developmental stage involving germ layer specification and axes formation, is a major point of failure in human development, contributing to pregnancy loss and congenital malformations.
Joseph Rufo, Chongxu Qiu, Dasol Han, Naomi Baxter, Gabrielle Daley, Jasmine Dhillon, Felix Wong, James J. Collins, Maxwell Z. Wilson   +8 more
doaj   +1 more source

A Commander-independent function of COMMD3 in endosomal trafficking

eLife
Endosomal recycling is a branch of intracellular membrane trafficking that retrieves endocytosed cargo proteins from early and late endosomes to prevent their degradation in lysosomes.
Galen T Squiers, Chun Wan, James Gorder, Harrison Puscher, Jingshi Shen   +4 more
doaj   +1 more source

Cellular automata and dynamical systems [PDF]

In this thesis we investigate the theoretical nature of the mathematical structures termed cellular automata. Chapter 1: Reviews the origin and history of cellular automata in order to place the current work into context.
Clewlow, Les
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source