Results 201 to 210 of about 358,177 (298)

The history of the cellular slime moulds as a “model system≓ for developmental biology

Journal of Biosciences, 1999
openaire   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Oocyte Aging as a Systems-Level Failure of Cellular Quality Control Networks: Insights from Comparative Biology. [PDF]

Biology (Basel)
Sochaczewska M, Tworzydlo W.
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Cellular ageing monographs in developmental biology, vol. 17 [PDF]

FEBS Letters, 1986
openaire   +1 more source

(In Vitro Cellular&Developmental Biology Plant,35:061-069)A protocol for efficient transformation and regeneration of Carica papaya L.

, 2014
Souza, M., Gonsalves, D., Cai, W., Gonsalves, C., Zhu, H. Y., Jan, Fuh-Jyh, Fermin, G., Sarindu, N., Tennant, P.   +8 more
core  

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Integrative precision oncology in neuroblastoma: multi-omics biomarkers, molecular targets, and immunotherapeutic strategies. [PDF]

Front Oncol
Singh A, Goel N, Mehndiratta S, Chaudhry A, Kaur M, Swain SK, Prabhakar P, Misra A, Rishi B.   +8 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Traffic Jams in the Brain: How Kinesin Dysfunction Shapes Neurodevelopmental Disorders. [PDF]

Curr Issues Mol Biol
Shams Nosrati MS, Doustmohammadi M, Dostmohammadi A, Kakavand Hamidi A, Boogari M, Hoseini Tavassol Z, Khosravinejat S, Asgari M, Shafiei M, Nemati AH, Romano F, Capra V, Sterlini B, Darbalaei M, Salehi M, Omrani MD, Zara F, Kibar Z, Miyamoto T, Scala M.   +19 more
europepmc   +1 more source