Results 21 to 30 of about 338,218 (160)

Noise reduction as an emergent property of single-cell aging

Nature Communications, 2017
Gene expression is a noisy process, but it is not known how noise in gene expression changes during the aging of single cells. Here the authors show that noise decreases during normal aging, and provide support for aging-associated increases in chromatin
Ping Liu, Ruijie Song, Gregory L. Elison, Weilin Peng, Murat Acar   +4 more
doaj   +1 more source

Sis2 regulates yeast replicative lifespan in a dose-dependent manner

Nature Communications, 2023
Application of microfluidic platforms facilitated high-precision measurements of yeast replicative lifespan (RLS); however, comparative quantification of lifespan across strain libraries has been missing.
Tolga T. Ölmez, David F. Moreno, Ping Liu, Zane M. Johnson, Madeline M. McGinnis, Benjamin P. Tu, Mark Hochstrasser, Murat Acar   +7 more
doaj   +1 more source

Partial differential equations for self-organization in cellular and developmental biology [PDF]

Nonlinearity, 2008
Understanding the mechanisms governing and regulating the emergence of structure and heterogeneity within cellular systems, such as the developing embryo, represents a multiscale challenge typifying current integrative biology research, namely, explaining the macroscale behaviour of a system from microscale dynamics.
Baker, R, Gaffney, E, Maini, P
openaire   +2 more sources

Spatial self-organization resolves conflicts between individuality and collective migration

Nature Communications, 2018
How bacteria migrate collectively despite individual phenotypic variation is not understood. Here, the authors show that cells spontaneously sort themselves within moving bands such that variations in individual tumble bias, a determinant of gradient ...
X. Fu, S. Kato, J. Long, H. H. Mattingly, C. He, D. C. Vural, S. W. Zucker, T. Emonet   +7 more
doaj   +1 more source

An efficient multiplex approach to CRISPR/Cas9 gene editing in citrus

Plant Methods
CRISPR/Cas9-mediated gene editing requires high efficiency to be routinely implemented, especially in species which are laborious and slow to transform. This requirement intensifies further when targeting multiple genes simultaneously, which is required ...
Cintia H. D. Sagawa, Geoffrey Thomson, Benoit Mermaz, Corina Vernon, Siqi Liu, Yannick Jacob, Vivian F. Irish   +6 more
doaj   +1 more source

Fibronectin is a smart adhesive that both influences and responds to the mechanics of early spinal column development

eLife, 2020
An extracellular matrix of Fibronectin adheres the neural tube to the two flanking columns of paraxial mesoderm and is required for normal vertebrate development.
Emilie Guillon, Dipjyoti Das, Dörthe Jülich, Abdel-Rahman Hassan, Hannah Geller, Scott Holley   +5 more
doaj   +1 more source

Progress and gaps of extracellular vesicle-mediated intercellular cargo transfer in the central nervous system

Communications Biology, 2022
The current state and limitations of research on extracellular vesicles in central nervous system (CNS) signaling are discussed, with particular focus on EV-mediated cargo transfer.
Chun Wan, Michael H. B. Stowell, Jingshi Shen   +2 more
doaj   +1 more source

Enhanced eMAGE applied to identify genetic factors of nuclear hormone receptor dysfunction via combinatorial gene editing

Nature Communications
Technologies that generate precise combinatorial genome modifications are well suited to dissect the polygenic basis of complex phenotypes and engineer synthetic genomes.
Peter N. Ciaccia, Zhuobin Liang, Anabel Y. Schweitzer, Eli Metzner, Farren J. Isaacs   +4 more
doaj   +1 more source

Expression of Normally Repressed Myosin Heavy Chain 7b in the Mammalian Heart Induces Dilated Cardiomyopathy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background In mammals, muscle contraction is controlled by a family of 10 sarcomeric myosin motors. The expression of one of its members, MYH7b, is regulated by alternative splicing, and while the protein is restricted to specialized muscles such as ...
Angela K. Peter, Alberto C. Rossi, Massimo Buvoli, Christopher D. Ozeroff, Claudia Crocini, Amy R. Perry, Ada E. Buvoli, Lindsey A. Lee, Leslie A. Leinwand   +8 more
doaj   +1 more source

TSPAN12 Is a Norrin Co-receptor that Amplifies Frizzled4 Ligand Selectivity and Signaling

Cell Reports, 2017
Accessory proteins in Frizzled (FZD) receptor complexes are thought to determine ligand selectivity and signaling amplitude. Genetic evidence indicates that specific combinations of accessory proteins and ligands mediate vascular β-catenin signaling in ...
Maria B. Lai, Chi Zhang, Jianli Shi, Verity Johnson, Lavan Khandan, John McVey, Michael W. Klymkowsky, Zhe Chen, Harald J. Junge   +8 more
doaj   +1 more source