Results 21 to 30 of about 16,736 (251)

Noise reduction as an emergent property of single-cell aging

Nature Communications, 2017
Gene expression is a noisy process, but it is not known how noise in gene expression changes during the aging of single cells. Here the authors show that noise decreases during normal aging, and provide support for aging-associated increases in chromatin
Ping Liu, Ruijie Song, Gregory L. Elison, Weilin Peng, Murat Acar   +4 more
doaj   +1 more source

Quantitative analysis of cell shape and the cytoskeleton in developmental biology

, 2018
Computational approaches that enable quantification of microscopy data have revolutionized the field of developmental biology. Due to its inherent complexity, elucidating mechanisms of development requires sophisticated analysis of the structure, shape ...
Martin, Adam C, Yevick, Hannah G., Hannah G. Yevick, Martin, Adam C., Adam C. Martin   +4 more
core   +1 more source

HyperNCA: Growing Developmental Networks with Neural Cellular Automata [PDF]

, 2022
In contrast to deep reinforcement learning agents, biological neural networks are grown through a self-organized developmental process. Here we propose a new hypernetwork approach to grow artificial neural networks based on neural cellular automata (NCA).
Sudhakaran, Shyam, Glanois, Claire, Risi, Sebastian, Najarro, Elias; id_orcid   +3 more
core   +3 more sources

An efficient multiplex approach to CRISPR/Cas9 gene editing in citrus

Plant Methods
CRISPR/Cas9-mediated gene editing requires high efficiency to be routinely implemented, especially in species which are laborious and slow to transform. This requirement intensifies further when targeting multiple genes simultaneously, which is required ...
Cintia H. D. Sagawa, Geoffrey Thomson, Benoit Mermaz, Corina Vernon, Siqi Liu, Yannick Jacob, Vivian F. Irish   +6 more
doaj   +1 more source

Spatial self-organization resolves conflicts between individuality and collective migration

Nature Communications, 2018
How bacteria migrate collectively despite individual phenotypic variation is not understood. Here, the authors show that cells spontaneously sort themselves within moving bands such that variations in individual tumble bias, a determinant of gradient ...
X. Fu, S. Kato, J. Long, H. H. Mattingly, C. He, D. C. Vural, S. W. Zucker, T. Emonet   +7 more
doaj   +1 more source

Sis2 regulates yeast replicative lifespan in a dose-dependent manner

Nature Communications, 2023
Application of microfluidic platforms facilitated high-precision measurements of yeast replicative lifespan (RLS); however, comparative quantification of lifespan across strain libraries has been missing.
Tolga T. Ölmez, David F. Moreno, Ping Liu, Zane M. Johnson, Madeline M. McGinnis, Benjamin P. Tu, Mark Hochstrasser, Murat Acar   +7 more
doaj   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Protein interference applications in cellular and developmental biology using DARPins that recognize GFP and mCherry [PDF]

Biology Open, 2014
ABSTRACT Protein–protein interactions are crucial for cellular homeostasis and play important roles in the dynamic execution of biological processes. While antibodies represent a well-established tool to study protein interactions of extracellular domains and secreted proteins, as well as in fixed and permeabilized cells, they usually ...
Brauchle, Michael, Hansen, Simon, Caussinus, Emmanuel, Lenard, Anna, Ochoa-Espinosa, Amanda, Scholz, Oliver, Sprecher, Simon G., Plückthun, Andreas, Affolter, Markus   +8 more
openaire   +7 more sources

Synthetic cargo adaptors reveal molecular features that enhance dynein activation

Nature Communications
Cytoplasmic dynein-1 (dynein) facilitates the microtubule-based retrograde trafficking of all cellular cargo. To become active, dynein binds dynactin and one of many cargo-specific adaptors forming the dynein-dynactin-adaptor transport complex.
Aravintha Siva, John P. Gillies, Ashley de Borchgrave, Sharon R. Garrott, Rishi Mishra, Rita El Jbeily, Reagan S. Clarke, Cameron Conklin, Daytan Gibson, Juliana L. Zang, Morgan E. DeSantis   +10 more
doaj   +1 more source

Fibronectin is a smart adhesive that both influences and responds to the mechanics of early spinal column development

eLife, 2020
An extracellular matrix of Fibronectin adheres the neural tube to the two flanking columns of paraxial mesoderm and is required for normal vertebrate development.
Emilie Guillon, Dipjyoti Das, Dörthe Jülich, Abdel-Rahman Hassan, Hannah Geller, Scott Holley   +5 more
doaj   +1 more source