Results 11 to 20 of about 333,263 (245)

Cellular and Developmental Biology of TRPM7 Channel-Kinase: Implicated Roles in Cancer. [PDF]

Cells, 2014
The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously expressed cation-permeable ion channel with intrinsic kinase activity that plays important roles in various physiological functions. Biochemical and electrophysiological studies, in combination with molecular analyses of TRPM7, have generated insights into its ...
Yee NS, Kazi AA, Yee RK.
europepmc   +5 more sources

Recent Advances in the Cellular and Developmental Biology of Phospholipases in Plants. [PDF]

Front Plant Sci, 2019
Phospholipases (PLs) are lipid-hydrolyzing enzymes known to have diverse signaling roles during plant abiotic and biotic stress responses. They catalyze lipid remodeling, which is required to generate rapid responses of plants to environmental cues. Moreover, they produce second messenger molecules, such as phosphatidic acid (PA) and thus trigger or ...
Takáč T, Novák D, Šamaj J.
europepmc   +5 more sources

Protein interference applications in cellular and developmental biology using DARPins that recognize GFP and mCherry. [PDF]

Biol Open, 2014
ABSTRACT Protein–protein interactions are crucial for cellular homeostasis and play important roles in the dynamic execution of biological processes. While antibodies represent a well-established tool to study protein interactions of extracellular domains and secreted proteins, as well as in fixed and permeabilized cells, they usually ...
Brauchle M, Hansen S, Caussinus E, Lenard A, Ochoa-Espinosa A, Scholz O, Sprecher SG, Plückthun A, Affolter M.   +8 more
europepmc   +9 more sources

Illuminating developmental biology with cellular optogenetics [PDF]

Current Opinion in Biotechnology, 2018
In developmental biology, localization is everything. The same stimulus-cell signaling event or expression of a gene-can have dramatically different effects depending on the time, spatial position, and cell types in which it is applied. Yet the field has long lacked the ability to deliver localized perturbations with high specificity in vivo.
Heath E Johnson, Jared E Toettcher
openaire   +2 more sources

Causal role for sleep-dependent reactivation of learning-activated sensory ensembles for fear memory consolidation

Nature Communications, 2021
Learning-activated engram neurons play a critical role in memory recall but the role of these neurons in offline memory consolidation is unclear. The authors show that sleep-associated reactivation of learning-activated sensory neurons is necessary for ...
Brittany C. Clawson, Emily J. Pickup, Amy Ensing, Laura Geneseo, James Shaver, John Gonzalez-Amoretti, Meiling Zhao, A. Kane York, Femke Roig Kuhn, Kevin Swift, Jessy D. Martinez, Lijing Wang, Sha Jiang, Sara J. Aton   +13 more
doaj   +1 more source

GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway

Nature Communications, 2022
Lysosomal biogenesis errors often result in diseases including mucolipidosis. Here Zhang and Yang et al. identify TMEM251/GCAF as a mannose-6-phosphate modification regulator that is necessary for correct lysosomal targeting, and classify Mucolipidosis ...
Weichao Zhang, Xi Yang, Yingxiang Li, Linchen Yu, Bokai Zhang, Jianchao Zhang, Woo Jung Cho, Varsha Venkatarangan, Liang Chen, Bala Bharathi Burugula, Sarah Bui, Yanzhuang Wang, Cunming Duan, Jacob O. Kitzman, Ming Li   +14 more
doaj   +1 more source

Whole body regeneration and developmental competition in two botryllid ascidians

EvoDevo, 2021
Background Botryllid ascidians are a group of marine invertebrate chordates that are colonial and grow by repeated rounds of asexual reproduction to form a colony of individual bodies, called zooids, linked by a common vascular network.
Shane Nourizadeh, Susannah Kassmer, Delany Rodriguez, Laurel S. Hiebert, Anthony W. De Tomaso   +4 more
doaj   +1 more source

GPI-AP release in cellular, developmental, and reproductive biology [PDF]

Journal of Lipid Research, 2016
Glycosylphosphatidylinositol-anchored proteins (GPI-APs) contain a covalently linked GPI anchor located on outer cell membranes. GPI-APs are ubiquitously conserved from protozoa to vertebrates and are critical for physiological events such as development, immunity, and neurogenesis in vertebrates.
Fujihara, Yoshitaka, Ikawa, Masahito
openaire   +4 more sources

Enhanced germline stem cell longevity in Drosophila diapause

Nature Communications, 2022
Drosophila enter adult reproductive diapause in low temperatures and short day, halting ovarian development yet preserving fertility. Here the authors show that ovarian arrest in diapause is distinct from other stress responses and that despite DNA ...
Sreesankar Easwaran, Matthew Van Ligten, Mackenzie Kui, Denise J. Montell   +3 more
doaj   +1 more source

Cell surface-localized CsgF condensate is a gatekeeper in bacterial curli subunit secretion

Nature Communications, 2023
Curli are functional amyloids present on the outer membrane of E. coli. CsgF is required for the proper assembly of curli. Here, we found that the CsgF phase separates in vitro and that the ability of CsgF variants to phase-separate is tightly correlated
Hema M. Swasthi, Joseph L. Basalla, Claire E. Dudley, Anthony G. Vecchiarelli, Matthew R. Chapman   +4 more
doaj   +1 more source