Results 21 to 30 of about 358,177 (298)
Lithium-sensing riboswitch classes regulate expression of bacterial cation transporter genes
Scientific Reports, 2022 Lithium is rare in Earth’s crust compared to the biologically relevant alkali metal cations sodium and potassium but can accumulate to toxic levels in some environments.
Neil White +4 more
doaj +1 more source
Loss of FTO Antagonises Wnt Signaling and Leads to Developmental Defects Associated with Ciliopathies [PDF]
, 2014 Common intronic variants in the Human fat mass and obesity-associated gene (FTO) are found to be associated with an increased risk of obesity. Overexpression of FTO correlates with increased food intake and obesity, whilst loss-of-function results in ...
Rosa Maria Roccasecca (519728) +40 more
core +1 more source
Nature Communications, 2017 Multiple mechanisms regulate Wnt/ß-catenin signalling. Zhanget al. describe a novel regulatory pathway and show that the activator of canonical Wnt signalling, Norrin, triggers endocytosis of its receptor Frizzled4 by promoting Frizzled4 ubiquitination.
Chi Zhang +5 more
doaj +1 more source
Fsh stimulates Leydig cell Wnt5a production, enriching zebrafish type A spermatogonia [PDF]
, 2018 Follicle-stimulating hormone (Fsh) modulates vertebrate spermatogenesis by regulating somatic cell functions in the testis. We have found previously that zebrafish Fsh stimulated the differentiating proliferation of type A undifferentiated spermatogonia (
Sub Developmental Biology +5 more
core +2 more sources
Sugar sensation and mechanosensation in the egg-laying preference shift of Drosophila suzukii
eLife, 2022 The agricultural pest Drosophila suzukii differs from most other Drosophila species in that it lays eggs in ripe, rather than overripe, fruit. Previously, we showed that changes in bitter taste sensation accompanied this adaptation (Dweck et al., 2021 ...
Wanyue Wang +5 more
doaj +1 more source
Split Intein-Mediated Protein Ligation for detecting protein-protein interactions and their inhibition [PDF]
, 2020 Here, to overcome many limitations accompanying current available methods to detect protein-protein interactions (PPIs), we develop a live cell method called Split Intein-Mediated Protein Ligation (SIMPL).
Lyakisheva, Anna +12 more
core +1 more source
Nature Communications, 2021 Parasitoids exploit host bodies for reproduction, selecting for host defences. A new host defence is reported, in which adult Drosophila accelerate mating behaviour at the sight of certain parasitoid wasps, mediated by the upregulation of a nervous ...
Shimaa A. M. Ebrahim +2 more
doaj +1 more source
XPO5 promotes primary miRNA processing independently of RanGTP
Nature Communications, 2020 XPO5 mediates nuclear export of miRNA hairpin precursors (pre-miRNAs) through a RanGTP-dependent binding. Here the authors employ HITS-CLIP and biochemical analysis and show that XPO5 binds and promotes nuclear processing of clustered pri-miRNAs, with ...
Jingjing Wang +6 more
doaj +1 more source
Non‐genetic diversity modulates population performance
Molecular Systems Biology, 2016 Biological functions are typically performed by groups of cells that express predominantly the same genes, yet display a continuum of phenotypes. While it is known how one genotype can generate such non‐genetic diversity, it remains unclear how different
Adam James Waite +5 more
doaj +1 more source
Noise reduction as an emergent property of single-cell aging
Nature Communications, 2017 Gene expression is a noisy process, but it is not known how noise in gene expression changes during the aging of single cells. Here the authors show that noise decreases during normal aging, and provide support for aging-associated increases in chromatin
Ping Liu +4 more
doaj +1 more source