Results 111 to 120 of about 1,611,391 (358)

Base-editing corrects metabolic abnormalities in a humanized mouse model for glycogen storage disease type-Ia

Nature Communications
Glycogen storage disease type-Ia patients, deficient in the G6PC1 gene encoding glucose-6-phosphatase-α, lack blood glucose control, resulting in life-threatening hypoglycemia. Here we show our humanized mouse model, huR83C, carrying the pathogenic G6PC1-
Irina Arnaoutova, Yvonne Aratyn-Schaus, Lisa Zhang, Michael S. Packer, Hung-Dar Chen, Cheol Lee, Sudeep Gautam, Francine M. Gregoire, Dominique Leboeuf, Steven Boule, Thomas P. Fernandez, Victoria Huang, Lo-I Cheng, Genesis Lung, Brianna Bannister, Jeremy Decker, Thomas Leete, Lan S. Shuang, Caroline Bock, Prachi Kothiyal, Phil Grayson, Ka W. Mok, Jeffrey J. Quinn, Lauren Young, Luis Barrera, Giuseppe Ciaramella, Brian C. Mansfield, Janice Y. Chou   +27 more
doaj   +1 more source

Modelling acute myeloid leukaemia in a continuum of differentiation states

Letters in Biomathematics, 2018
Here we present a mathematical model of movement in an abstract space representing states of cellular differentiation. We motivate this work with recent examples that demonstrate a continuum of cellular differentiation using single-cell RNA-sequencing ...
H. Cho, K. Ayers, L. de Pills, Y.-H. Kuo, J. Park, A. Radunskaya, R. C. Rockne   +6 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

An Efficient In Vitro Shoot Organogenesis and Comparative GC-MS Metabolite Profiling of Gaillardia pulchella Foug

Horticulturae
Gaillardia pulchella Foug. is a widely studied plant because of its high pharmacological and ornamental value. The leaves of G. pulchella were used for inducing callus and subsequent plant regeneration as it is the primary source of phytocompounds.
Mahima Bansal, A. Mujib, Yashika Bansal, Yaser Hassan Dewir, Nóra Mendler-Drienyovszki   +4 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Aneuploidy as a cause of impaired chromatin silencing and mating-type specification in budding yeast

eLife, 2017
Aneuploidy and epigenetic alterations have long been associated with carcinogenesis, but it was unknown whether aneuploidy could disrupt the epigenetic states required for cellular differentiation.
Wahid A Mulla, Chris W Seidel, Jin Zhu, Hung-Ji Tsai, Sarah E Smith, Pushpendra Singh, William D Bradford, Scott McCroskey, Anjali R Nelliat, Juliana Conkright, Allison Peak, Kathryn E Malanowski, Anoja G Perera, Rong Li   +13 more
doaj   +1 more source

Cellular communication and differentiation [PDF]

Arthritis & Rheumatism, 1979
E A, Boyse, H, Cantor
openaire   +2 more sources

Cellular differentiation in the leaf

Current Opinion in Cell Biology, 1998
The past year has seen significant advances in our understanding of the mechanisms that regulate cellular differentiation in the leaf. It has been suggested that a common developmental pathway involving MYB-like transcription factors is responsible for distinguishing between cellular identities in the epidermis and that nuclear-cytoplasmic partitioning
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

CD34+ cells cultured in stem cell factor and interleukin-2 generate CD56+ cells with antiproliferative effects on tumor cell lines

Journal of Translational Medicine, 2005
In vitro stimulation of CD34+ cells with IL-2 induces NK cell differentiation. In order to define the stages of NK cell development, which influence their generation from CD34 cells, we cultured G-CSF mobilized peripheral blood CD34+ cells in the ...
Hensel Nancy, Li Jongming, Melenhorst Jos, Rezvani Katayoun, Provenzano Maurizio, Sconocchia Giuseppe, Barrett A John   +6 more
doaj   +1 more source