Results 171 to 180 of about 4,342,740 (357)

Editorial: Mechanisms of cellular differentiation, organ development, and novel model systems. [PDF]

Front Cell Dev Biol, 2022
Hendriks D, Artegiani B, Kretzschmar K.
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

CAMBIOS FENOTÍPICOS DEL EPITELIO MAMARIO INDUCIDOS POR SU ENTORNO CELULAR

Revista Chilena de Obstetricia y Ginecología, 2004
Se presenta una revisión bibliográfica relacionada con la funcionalidad de la matriz extracelular y sus distintos componentes en el sentido de gatillar y modular el proceso biológico de la diferenciación celular, con especial énfasis en los diferentes ...
Ricardo Cornejo U.
doaj  

Vertical Vibration of Mouse Osteoblasts Promotes Cellular Differentiation and Cell Cycle Progression and Induces Aging In Vitro. [PDF]

Biomedicines, 2023
Choi D, Ishii T, Ishikawa M, Ootake T, Kamei H, Nagai K, Sueishi K.   +6 more
europepmc   +1 more source

Gelatin—Hyaluronic Acid Hydrogels with Tuned Stiffness to Counterbalance Cellular Forces and Promote Cell Differentiation

, 2016
Sara Poveda‐Reyes, Vladimíra Moulisová, Esther Sanmartín‐Masiá, Luis Quintanilla‐Sierra, Manuel Salmerón‐Sánchez, Gloria Gallego Ferrer   +5 more
openalex   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Epigenetic Regulation of Development, Cellular Differentiation, and Disease Progression/Protection in Adults. [PDF]

Cells, 2022
Ryznar RJ, Phibbs L, Onat E, Van Winkle LJ.   +3 more
europepmc   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Nifedipine Ameliorates Cellular Differentiation Defects of Smn-Deficient Motor Neurons and Enhances Neuromuscular Transmission in SMA Mice. [PDF]

Int J Mol Sci, 2023
Tejero R, Alsakkal M, Hennlein L, Lopez-Cabello AM, Jablonka S, Tabares L.   +5 more
europepmc   +1 more source

The Role of Alternative Splicing in the Control of Immune Homeostasis and Cellular Differentiation [PDF]

, 2015
Mehmet Yabas, Hannah Elliott, Gerard F. Hoyne   +2 more
openalex   +1 more source