Dissecting the roles of MBD2 isoforms and domains in regulating NuRD complex function during cellular differentiation. [PDF]
Nat Commun, 2023 Schmolka N +9 more
europepmc +1 more source
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
Chromatin loop dynamics during cellular differentiation are associated with changes to both anchor and internal regulatory features. [PDF]
Genome Res, 2023 Bond ML +7 more
europepmc +1 more source
The metabolism of macromolecules during the differentiation of myxamoebae of the cellular slime mould Dictyostelium discoideum containing different amounts of glycogen [PDF]
, 1974 B.D. Hames, John Ashworth
openalex +1 more source
Molecular Oncology, EarlyView.In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková +14 more
wiley +1 more source
MIF-like domain containing protein orchestrates cellular differentiation and virulence in the fungal pathogen Magnaporthe oryzae. [PDF]
iScience, 2023 Galli M +12 more
europepmc +1 more source
Gonadal Hormones and Brain Development: Cellular Aspects of Sexual Differentiation [PDF]
, 1978 C. Dominique Toran‐Allerand
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Molecular Oncology, EarlyView.In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim +11 more
wiley +1 more source
Enzyme synthesis in the cellular slime mould Dictyostelium discoideum during the differentiation of myxamoebae grown axenically [PDF]
, 1972 J. Quance, John Ashworth
openalex +1 more source
Molecular Oncology, EarlyView.This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima +6 more
wiley +1 more source