Results 181 to 190 of about 1,611,391 (358)

Chromatin loop dynamics during cellular differentiation are associated with changes to both anchor and internal regulatory features. [PDF]

Genome Res, 2023
Bond ML, Davis ES, Quiroga IY, Dey A, Kiran M, Love MI, Won H, Phanstiel DH.   +7 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Diagnostic Pitfalls of Differentiating Cellular Digital Fibroma from Superficial Acral Fibromyxoma [PDF]

, 2015
Jin Yong Lee, So Eun Park, Soo Jung Shin, Chul Woo Kim, Sang Seok Kim   +4 more
openalex   +1 more source

MIF-like domain containing protein orchestrates cellular differentiation and virulence in the fungal pathogen Magnaporthe oryzae. [PDF]

iScience, 2023
Galli M, Jacob S, Zheng Y, Ghezellou P, Gand M, Albuquerque W, Imani J, Allasia V, Coustau C, Spengler B, Keller H, Thines E, Kogel KH.   +12 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Application of Low-Frequency Alternating Current Electric Fields Via Interdigitated Electrodes: Effects on Cellular Viability, Cytoplasmic Calcium, and Osteogenic Differentiation of Human Adipose-Derived Stem Cells

, 2010
Seth D. McCullen, John P. McQuilling, Robert M. Grossfeld, Jane L. Lubischer, Laura Clarke, Elizabeth G. Loboa   +5 more
openalex   +2 more sources

13-cis-retinoic acid induces cellular differentiation and durable remission in refractory cutaneous ki-1 lymphoma [PDF]

, 1991
Jyh‐Ming Chow, Ann‐Lii Cheng, Ih‐Jen Su, Chiu‐Hwa Wang   +3 more
openalex   +1 more source

Editorial: Mechanisms of cellular differentiation, organ development, and novel model systems. [PDF]

Front Cell Dev Biol, 2022
Hendriks D, Artegiani B, Kretzschmar K.
europepmc   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Vertical Vibration of Mouse Osteoblasts Promotes Cellular Differentiation and Cell Cycle Progression and Induces Aging In Vitro. [PDF]

Biomedicines, 2023
Choi D, Ishii T, Ishikawa M, Ootake T, Kamei H, Nagai K, Sueishi K.   +6 more
europepmc   +1 more source