Results 211 to 220 of about 1,611,391 (358)

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Cellular prion protein and γ-synuclein overexpression in LS 174T colorectal cancer cell drives endothelial proliferation-to-differentiation switch

, 2018
Sing-Hui Ong, Kai-Wey Goh, Cornelius Kwang-Lee Chieng, Yee‐How Say   +3 more
openalex   +1 more source

BNIP‐2 Activation of Cellular Contractility Inactivates YAP for H9c2 Cardiomyoblast Differentiation

, 2022
Darren Chen Pei Wong, Jingwei Xiao, Ti Weng Chew, Meng Pan, Chang Jie Mick Lee, Jing Wen Ang, Ivan Yow, T. Thivakar, Matthew Ackers‐Johnson, Jia Wen Nicole Lee, Roger Foo, Pakorn Kanchanawong, Boon Chuan Low   +12 more
openalex   +1 more source

Plasticity and the evolution of group-level regulation of cellular differentiation in the volvocine algae. [PDF]

Proc Biol Sci
Davison DR, Nedelcu AM, Eneji OA, Michod RE.   +3 more
europepmc   +1 more source

Metabolism-based targeting of MYC via MPC-SOD2 axis-mediated oxidation promotes cellular differentiation in group 3 medulloblastoma. [PDF]

Nat Commun, 2023
Martell E, Kuzmychova H, Kaul E, Senthil H, Chowdhury SR, Morrison LC, Fresnoza A, Zagozewski J, Venugopal C, Anderson CM, Singh SK, Banerji V, Werbowetski-Ogilvie TE, Sharif T.   +13 more
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Heme-deficient metabolism and impaired cellular differentiation as an evolutionary trade-off for human infectivity in Trypanosoma brucei gambiense. [PDF]

Nat Commun, 2022
Horáková E, Lecordier L, Cunha P, Sobotka R, Changmai P, Langedijk CJM, Abbeele JVD, Vanhollebeke B, Lukeš J.   +8 more
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Integrated single-cell transcriptomics and spatial metabolomics unveil cellular differentiation and ginsenosides biosynthesis in <i>Panax</i> root tips. [PDF]

Hortic Res
Yang L, Yang Z, Liu M, Wang S, Wu H, Yang Q, Huang L, Yang Y, Cui X, Liu Y.   +9 more
europepmc   +1 more source

Genomes of Novel Myxococcota Reveal Severely Curtailed Machineries for Predation and Cellular Differentiation. [PDF]

Appl Environ Microbiol, 2021
Murphy CL, Yang R, Decker T, Cavalliere C, Andreev V, Bircher N, Cornell J, Dohmen R, Pratt CJ, Grinnell A, Higgs J, Jett C, Gillett E, Khadka R, Mares S, Meili C, Liu J, Mukhtar H, Elshahed MS, Youssef NH.   +19 more
europepmc   +1 more source