Results 101 to 110 of about 11,040,764 (238)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Deadlock Avoidance in Cellular Manufacturing Systems
, 1998 We develop control policies to avoid deadlocks in cellular manufacturing systems (CMSs). We take advantage of the structure of a CMS to develop a distributed control system in which each cell is controlled locally and independently.
FANTI, Maria Pia +2 more
core +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
A control methodology for automated manufacturing [PDF]
, 1991 The application of computers in the manufacturing industry has substantially altered the control procedures used to program a whole manufacturing process. Currently, one the problems which automated manufacturing systems are experiencing is the lack of a
Nahavandi, Saeid
core
Virtual and Physical Prototyping3D printing technologies provide unprecedented design flexibility for fabricating cellular materials with geometrically intricate topologies unattainable through conventional manufacturing.
Xinxin Wang +4 more
doaj +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
Relations between cells in cellular manufacturing [PDF]
The paper considers a (static) portfolio system that satisfies adding-up contraints and the gross substitution theorem. The paper shows the relationship of the two conditions to the weak dominant diagonal property of the matrix of interest rate ...
Riezebos, J., Gaalman, G.J.C.
core
Performance comparison of cellular manufacturing configurations in different demand profiles
, 2012 Cellular manufacturing systems (CMSs) are an effective response in the economic environment characterized by high variability of market. The aim of this chapter is to compare different configurations of cellular models through the main performance. These
AMBRICO, MICHELE, RENNA, PAOLO
core +1 more source