Results 91 to 100 of about 11,040,764 (238)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Parameter optimization of the program trajectory of the cellular concrete autoclaving control system

MATEC Web of Conferences, 2017
Manufacturing of cellular-concrete products that are widely used in modern construction involves high energy consumption attributable mostly to the process of autoclaving. Insufficient elaboration of issues of mathematical description of autoclaving that
Galitskov Stanislav, Nazarov Maxim, Bolkhovetskiy Andrey   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A Comprehensive Mathematical Model for the Design of a Dynamic Cellular Manufacturing System Integrated with Production Planning and Several Manufacturing Attributes

International Journal of Industrial Engineering and Production Research, 2011
Dynamic cellular manufacturing systems,   Mixed-integer non-linear programming,   Production planning, Manufacturing attributes   This paper presents a novel mixed-integer non-linear programming model for the design of a dynamic cellular manufacturing ...
F. Khaksar-Haghani, N. Javadian, R. Tavakkoli-Moghaddam, A. Baboli, R. Kia   +4 more
doaj  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Manufacturing Cell Configuration Considering Worker Interest Concept Applying a Bi-Objective Programming Approach

International Journal of Industrial Engineering and Production Research, 2014
Generally, human resources play an important role in manufacturing systems as they can affect the work environment. One of the most important factors affecting the human resources is being an interactional interest among the workers in the workshops.
Iraj Mahdavi, Behrang Bootaki, Mohammd Mahdi Bootaki, Paydar   +2 more
doaj  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Knowledge-based diagnosis in manufacturing systems

, 2022
The article describes the known state-of-the-art of knowledge-based diagnostic systems in manufacturing. It relays, furthermore, practical experience in the development of knowledge-based systems and gives an example of a developed system for the ...
Spur, G., Specht, D.
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Comparação de desempenho entre as configurações celular, funcional e celular virtual através de simulação e projeto de experimentos [PDF]

, 2008
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia MecânicaA escolha adequada do sistema de gestão da produção e do arranjo físico no chão de fábrica é fundamental para a viabilidade de ...
Reaes, Paulo Antonio
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