Results 71 to 80 of about 11,040,764 (238)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A Manufacturing Informatics Framework for Manufacturing Sustainability Assessment. In : Re-engineering Manufacturing for Sustainability, Springer [PDF]

, 2013
Manufacturing firms that wish to improve their environmental performance of their product, process, and systems are faced with a complex task because manufacturing systems are very complex and they come in many forms and life expectancies.
ZHAO, Yaoyao Fiona, ANDRIANKAJA, Héry, PERRY, Nicolas   +2 more
core  

A bi-level mathematical programming for cell formation problem considering workers’ interest

International Journal of Industrial Engineering and Production Research, 2017
Nowadays, the necessity of manufacturers’ response to their customers’ needs and their fields of activities have extended widely. The cellular manufacturing systems have adopted reduced costs from mass-production systems and high flexibility ...
Bardia Behnia, Iraj Mahdavi, Babak Shirazi, Mohammad Mahdi Paydar   +3 more
doaj  

Study and Implementation of Lean Manufacturing in a Garment Manufacturing Company: Bangladesh Perspective [PDF]

Journal of Optimization in Industrial Engineering, 2011
Lean manufacturing is a systematic approach to identifying and eliminating wastes (non-value added activities) through continuous improvement by conveying the product at the pull of the customer in pursuit of production.
Ripon Kumar Chakrabortty, Sanjoy Kumar Paul   +1 more
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Improved sustainability in cellular manufacturing systems: Sensitivity analysis of penalty function driven NSG-II

Journal of Industrial Engineering and Management
Purpose: Research suggests that material handling costs account for 20-50% of production costs. Furthermore, these production cost could be reduced by 10-30% by dynamically changing the layout. We propose an integer programming model to sustainably solve
Melusi Mithi Sibanda, Jared Padayachee
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

A simulated annealing algorithm to determine a group layout and production plan in a dynamic cellular manufacturing system [PDF]

Journal of Optimization in Industrial Engineering, 2014
In this paper, a mixed-integer linearized programming (MINLP) model is presented to design a group layout (GL) of a cellular manufacturing system (CMS) in a dynamic environment with considering production planning (PP) decisions.
Reza KiA, Nikbakhsh Javadian, Reza Tavakkoli-Moghaddam   +2 more
doaj  

A study on development of a work instruction system for assembly cells based on analysis of learning processes

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2014
A cellular manufacturing system is a kind of lean and flexible manufacturing systems in which a worker or a group of workers carry out all assembly processes of a product.
Yoshitaka TANIMIZU, Satoru ISHII, Takashi YOKOTANI   +2 more
doaj   +1 more source