Results 31 to 40 of about 11,040,764 (238)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Two-Stage Adaptive Large Neighbourhood Search for Team Formation and Worker Assignment Problems in Cellular Manufacturing Systems

Applied Sciences, 2022
We present a novel mathematical programming model to address a team-oriented worker assignment problem, called the team formation and worker assignment problem (TFWAP).
Thanatat Pasupa, Sadami Suzuki
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Technical advances in NK cell-based cellular immunotherapy

Cancer Biology & Medicine, 2019
Natural killer (NK) cells represent a promising future for tumor immunotherapy because of their unique biological functions and characteristics. This review focuses on technical advances in NK cell-based cellular immunotherapy and summarizes the ...
Fang Fang, Wei Wang, Minhua Chen, Zhigang Tian, Weihua Xiao   +4 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Developing a Multi-objective Mathematical Model for Dynamic Cellular Manufacturing Systems [PDF]

Journal of Optimization in Industrial Engineering, 2011
This paper is in search of designing the cellular manufacturing systems (CMSs) under dynamic and flexible environment. CM is proper for small-to-medium lot production environment that helps the companies to produce variable kind of productions with at ...
Mohammad Saidi-Mehrabad, Seyedeh Maryam Mirnezami-ziabari   +1 more
doaj  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Solving generalized grouping problems in cellular manufacturing systems using a network flow model [PDF]

Journal of Intelligent Manufacturing and Special Equipment
PurposeThis study addresses the generalized grouping problem in cellular manufacturing systems (CMS) where parts may have multiple alternative process routes.
Md. Kutub Uddin, Md. Saiful Islam, Md Abrar Jahin, Md. Saiful Islam Seam, M. F. Mridha   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A comprehensive quadratic assignment problem for an integrated layout design of final assembly line and manufacturing feeder cells [PDF]

Decision Science Letters, 2017
Assembly lines and cellular manufacturing systems (CMSs) design have been widely used in the literature. However the integration of these manufacturing concepts is neglected in an environment where parts need to be assembled after production in different
Masoud Rabbani, Saeed Elahi, Babak Javadi   +2 more
doaj   +1 more source