Results 41 to 50 of about 11,040,764 (238)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Intelligent Manufacturing Systems for the Next Century
, 2022 S.73-77Up to now companies focussed their development and usage of flexible manufacturing systems mainly on the automation of the systems functions and the peripheral subsystems like transport and logistics. The main objective of this developments was to
Westkämper, E.
core +1 more source
Design of Cellular Manufacturing using Mathematical Programming: a comparative study with simulation modelling [PDF]
International Journal of Advanced Design and Manufacturing Technology, 2013 Machine-part family formation is one of major applications of group technology (GT). The machine cell formation problem in cellular manufacturing system (CMS) involves the decomposition of the manufacturing system into machine cells.
Hassan Farsijani +1 more
doaj
A Multi-Criteria Assessment of Manufacturing Cell Performance Using the AHP Method
Applied Sciences, 2022 Research of manufacturing cell design problems is still pertinent today, because new manufacturing strategies, such as mass customization, call for further improvement of the fundamental performance of cellular manufacturing systems.
Zuzana Soltysova +2 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
CELL FORMATION IN GROUP TECHNOLOGY: A SIMILARITY ORDER CLUSTERING APPROACH
South African Journal of Industrial Engineering, 2012 Grouping parts into families which can be produced by a cluster of machine cells is the cornerstone of cellular manufacturing, which in turn is the building block for flexible manufacturing systems.
Godfrey C. Onwubolu
doaj
An Integrated Model for Production Planning and Cell Formation in Cellular Manufacturing Systems
Journal of Applied Mathematics, 2013 Cellular manufacturing (CM) is a production approach directed towards reducing costs, as well as increasing system's flexibility in today's small-to-medium lot production environment.
Reza Raminfar +3 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source