Results 1 to 10 of about 57,422 (141)
The Role of Cellular Prion Protein in Cancer Biology: A Potential Therapeutic Target [PDF]
Frontiers in Oncology, 2021 Prion protein has two isoforms including cellular prion protein (PrPC) and scrapie prion protein (PrPSc). PrPSc is the pathological aggregated form of prion protein and it plays an important role in neurodegenerative diseases.
Manqiu Ding +3 more
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Redox mechanisms and their pathological role in prion diseases: The road to ruin.
PLoS Pathogens, 2023 Prion diseases, also known as transmissible spongiform encephalopathies, are rare, progressive, and fatal neurodegenerative disorders, which are caused by the accumulation of the misfolded cellular prion protein (PrPC).
Jereme G Spiers +2 more
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Potential Therapeutic Use of Stem Cells for Prion Diseases
Cells, 2023 Prion diseases are neurodegenerative disorders that are progressive, incurable, and deadly. The prion consists of PrPSc, the misfolded pathogenic isoform of the cellular prion protein (PrPC).
Mohammed Zayed +2 more
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Treatment of Prion Disease with Heterologous Prion Proteins. [PDF]
PLoS ONE, 2015 Prion diseases such as Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy in cattle, and scrapie in sheep are fatal neurodegenerative diseases for which there is no effective treatment.
Pamela J Skinner +9 more
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The cellular prion protein beyond prion diseases
Swiss Medical Weekly, 2020 The cellular prion protein (PrPC), a cell surface glycoprotein originally identified for its central role in prion diseases (also called transmissible spongiform encephalopathies), has recently been implicated in the pathogenesis of other ...
Giorgia Manni +7 more
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Genetic aspects of human prion diseases
Frontiers in Neurology, 2022 Human prion diseases are rapidly progressive and fatal neurodegenerative conditions caused by a disease-causing isoform of the native prion protein. The prion protein gene (PRNP) encodes for the cellular prion protein, which is the biological substrate ...
Brian S. Appleby +4 more
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The Quest for Cellular Prion Protein Functions in the Aged and Neurodegenerating Brain
Cells, 2020 Cellular (also termed ‘natural’) prion protein has been extensively studied for many years for its pathogenic role in prionopathies after misfolding.
Rosalina Gavín +3 more
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Frontiers in Molecular Biosciences, 2023 The presence of prion infectivity in the blood of patients affected by variant Creutzfeldt–Jakob disease (v-CJD), the human prion disease linked to the bovine spongiform encephalopathy (BSE), poses the risk of inter-human transmission of this fatal prion
Nina Jaffré +4 more
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Transport of Prions in the Peripheral Nervous System: Pathways, Cell Types, and Mechanisms
Viruses, 2022 Prion diseases are transmissible protein misfolding disorders that occur in animals and humans where the endogenous prion protein, PrPC, undergoes a conformational change into self-templating aggregates termed PrPSc.
Sam M. Koshy +2 more
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Frontiers in Neuroscience, 2015 Organotypic cerebellar slices represent a suitable model for characterizing and manipulating prion replication in complex cell environments. Organotypic slices recapitulate prion pathology and are amenable to drug testing in the absence of a blood-brain ...
Hanna eWolf +7 more
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