Cellular prion protein and its derived peptides: multifaceted roles in neurodegenerative diseases and potential as biomarkers [PDF]
Cell & BioscienceNeurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and transmissible spongiform encephalopathies (TSEs), share fundamental mechanisms of protein misfolding, synaptic dysfunction, and ...
Emanuela Mari +9 more
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The Role of Cellular Prion Protein in Cancer Biology: A Potential Therapeutic Target [PDF]
Frontiers in Oncology, 2021 Prion protein has two isoforms including cellular prion protein (PrPC) and scrapie prion protein (PrPSc). PrPSc is the pathological aggregated form of prion protein and it plays an important role in neurodegenerative diseases.
Manqiu Ding +3 more
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Pharmacological Agents Targeting the Cellular Prion Protein
Pathogens, 2018 Prion diseases are associated with the conversion of the cellular prion protein (PrPC), a glycoprotein expressed at the surface of a wide variety of cell types, into a misfolded conformer (the scrapie form of PrP, or PrPSc) that accumulates in brain ...
Maria Letizia Barreca +4 more
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The Cellular Prion Protein and the Hallmarks of Cancer [PDF]
Cancers, 2021 Pierre Laurent-Puig +2 more
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The Role of Cellular Prion Protein in Glioma Tumorigenesis Could Be through the Autophagic Mechanisms: A Narrative Review [PDF]
International Journal of Molecular Sciences, 2023 Daniele Armocida +2 more
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Redox mechanisms and their pathological role in prion diseases: The road to ruin
PLoS Pathogens, 2023 Prion diseases, also known as transmissible spongiform encephalopathies, are rare, progressive, and fatal neurodegenerative disorders, which are caused by the accumulation of the misfolded cellular prion protein (PrPC).
Jereme G. Spiers +2 more
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Potential Therapeutic Use of Stem Cells for Prion Diseases
Cells, 2023 Prion diseases are neurodegenerative disorders that are progressive, incurable, and deadly. The prion consists of PrPSc, the misfolded pathogenic isoform of the cellular prion protein (PrPC).
Mohammed Zayed +2 more
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Treatment of Prion Disease with Heterologous Prion Proteins. [PDF]
PLoS ONE, 2015 Prion diseases such as Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy in cattle, and scrapie in sheep are fatal neurodegenerative diseases for which there is no effective treatment.
Pamela J Skinner +9 more
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Genetic aspects of human prion diseases
Frontiers in Neurology, 2022 Human prion diseases are rapidly progressive and fatal neurodegenerative conditions caused by a disease-causing isoform of the native prion protein. The prion protein gene (PRNP) encodes for the cellular prion protein, which is the biological substrate ...
Brian S. Appleby +4 more
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The cellular prion protein beyond prion diseases
Swiss Medical Weekly, 2020 The cellular prion protein (PrPC), a cell surface glycoprotein originally identified for its central role in prion diseases (also called transmissible spongiform encephalopathies), has recently been implicated in the pathogenesis of other ...
Giorgia Manni +7 more
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