Results 171 to 180 of about 57,548 (261)

Epidemiology of progressive intellectual and neurological deterioration in UK children

Developmental Medicine &Child Neurology, Volume 68, Issue 3, Page 418-428, March 2026.
This study of PIND in UK children was carried out via the British Paediatric Surveillance Unit from 1997 to 2024. It identified six cases of vCJD. 2367 children had other diagnoses explain their deterioration. There were 259 other diseases in the diagnosed group.
Christopher M. Verity, Polly J. Maunder, Anne Marie Winstone, Suvankar Pal   +3 more
wiley   +1 more source

Identification of a Cardiac Glycoside Exhibiting Favorable Brain Bioavailability and Potency for Reducing Levels of the Cellular Prion Protein. [PDF]

Int J Mol Sci, 2022
Eid S, Zerbes T, Williams D, Wang X, Sackmann C, Meier S, Dulin NO, Nagorny P, Schmitt-Ulms G.   +8 more
europepmc   +1 more source

Mobile Powerhouses: Mitochondria Transfer via Tunnelling Nanotubes in Brain Health and Neurodegenerative Diseases

European Journal of Neuroscience, Volume 63, Issue 6, March 2026.
Within the brain microenvironment, mitochondria are preferentially transferred from glial cells to metabolically stressed neurons via tunnelling nanotubes (TNTs). This intercellular exchange restores bioenergetic homeostasis and contributes to mitochondrial quality control through transmitophagy.
Anna Henrich, Hannah Scheiblich
wiley   +1 more source

Characteristic distribution and molecular properties of normal cellular prion protein in human endocrine and exocrine tissues. [PDF]

Sci Rep, 2022
Koyama S, Noguchi H, Yagita K, Hamasaki H, Shijo M, Yoshimura M, Inoshita K, Sasagasako N, Honda H.   +8 more
europepmc   +1 more source

Co‐localization of tau and TDP‐43 after extracellular vesicle delivery to cells

The FEBS Journal, Volume 293, Issue 5, Page 1495-1515, March 2026.
Extracellular vesicles (EVs) derived from donor cells transfected with EGFP–2N4R‐tau or mCherry‐wtTDP‐43 were taken up by recipient cells, leading to cytosolic co‐localization of tau and TDP‐43. Molecular modeling revealed that tau and TDP‐43 directly interact through hydrogen bonding, suggesting a mechanistic link underlying their co‐pathology ...
Farhang Aliakbari, Kathryn Volkening, Zahra Nayeri, Aysegul Yucel Polat, Neil Donison, Jacqueline Palik, Michael J. Strong   +6 more
wiley   +1 more source

Cellular prion protein and calcium ions trigger the neurotoxicity of α-synuclein aggregates. [PDF]

Cell Biosci
Bigi A, Conti AC, Napolitano L, Fusco G, De Simone A, Chiti F, Cascella R, Cecchi C.   +7 more
europepmc   +1 more source

The Expression of Cellular Prion Protein, PrPC, Favors pTau Propagation and Blocks NMDAR Signaling in Primary Cortical Neurons. [PDF]

Cells, 2023
Rivas-Santisteban R, Raïch I, Aguinaga D, Saura CA, Franco R, Navarro G.   +5 more
europepmc   +1 more source

Exploring Molecular Mechanism of Fluoxetine in Animal Models of Depression via Integrated Metabolomic and Proteomic Analysis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 6, March 2026.
ABSTRACT Fluoxetine is a widely used antidepressant, yet integrated analyses of its molecular mechanism remain limited. This study systematically investigated potential molecular mechanisms underlying the antidepressant effects of fluoxetine by integrating these scattered data. Using the ProMENDA database, we identified metabolites and proteins altered
Yin Chen, Wei Tang, Xiangkun Tao, Chi Liu, Hailin Wu, Ning Wang, Cenyu Liao, Nanxi He, Yiwen Chen, Yiyun Liu, Dongfang Wang, Siwen Gui, Xiaogang Zhong, Yuan Liu, Bin Hua, Lining Yang, Juncai Pu, Peng Xie   +17 more
wiley   +1 more source

Cellular Prion Protein and Amyloid-β Oligomers in Alzheimer's Disease-Are There Connections? [PDF]

Int J Mol Sci
Fułek M, Hachiya N, Gachowska M, Beszłej JA, Bartoszewska E, Kurpas D, Kurpiński T, Adamska H, Poręba R, Urban S, Fułek K, Leszek J.   +11 more
europepmc   +1 more source