Results 261 to 269 of about 123,953 (269)
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High-efficiency cellular reprogramming with microfluidics
Nature Methods, 2016We report that the efficiency of reprogramming human somatic cells to induced pluripotent stem cells (hiPSCs) can be dramatically improved in a microfluidic environment. Microliter-volume confinement resulted in a 50-fold increase in efficiency over traditional reprogramming by delivery of synthetic mRNAs encoding transcription factors.
LUNI, CAMILLA +10 more
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A systems view of cellular reprogramming
Nature Methods, 2014The CellNet platform, based on cell- and tissue-specific gene regulatory networks, is used to evaluate cells converted to a particular fate by various methods.
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Cellular reprogramming by transcription factor engineering
Current Opinion in Genetics & Development, 2014Recent researches have identified multiple transcription factors as permissible reprogramming factors to pluripotency and lineage switching. The current standard strategy by ectopic factor overexpression however has intrinsic limitations in studying the reprogramming mechanism.
Xuefei Gao +5 more
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AI in cellular engineering and reprogramming
Biophysical JournalDuring the last decade, artificial intelligence (AI) has increasingly been applied in biophysics and related fields, including cellular engineering and reprogramming, offering novel approaches to understand, manipulate, and control cellular function. The potential of AI lies in its ability to analyze complex datasets and generate predictive models.
Sara Capponi, Shangying Wang
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The expanding horizon of MicroRNAs in cellular reprogramming
Progress in Neurobiology, 2017Research over the last few years in cellular reprogramming has enlightened the magical potential of microRNAs (miRNAs) in changing the cell fate from somatic to pluripotent. Recent investigations on exploring the role(s) of miRNAs in somatic cell reprogramming revealed that they target a wide range of molecules and refine their protein output.
Yogita K. Adlakha, Pankaj Seth
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Cellular reprogramming to reset epigenetic signatures
Molecular Aspects of Medicine, 2013The controlled differentiation of induced pluripotent stem cells (iPSC) towards clinically-relevant cell types has benefitted from epigenetic profiling of lineage-specific markers to confirm the phenotype of iPSC-derived cells. Mapping epigenetic marks throughout the genome has identified unique changes which occur in the DNA methylation profile of ...
Kyle J. Hewitt, Jonathan A. Garlick
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The mystique of cellular reprogramming
Current Opinion in Genetics & Development, 2013Patrick P.L. Tam, Huck-Hui Ng
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Cellular Reprogramming and Fate Conversion
2012Cellular reprogramming and fate conversion have long been recognized in somatic nuclear transfer and cell fusion experiments. The potency of specific transcription factors as cell fate determinants was first demonstrated by the discovery of MyoD, a master gene for skeletal muscle differentiation, and by the subsequent identification of several genes as
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