Results 101 to 110 of about 312,550 (342)
Mesenchymal stem cells as vectors for lung cancer therapy [PDF]
, 2013 Despite recent advances in treatment, lung cancer accounts for one third of all cancer-related deaths, underlining the need of development of new therapies.
Janes, SM, Kolluri, KK, Laurent, GJ
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Structure of 2,3,5-triphenyltetrazol-3-ium chloride hemipentahydrate
Acta Crystallographica Section E: Crystallographic CommunicationsThe title hydrated molecular salt, C19H15N4+·Cl−·2.5H2O, has two triphenyltetrazolium cations, two chloride anions and five water molecules in the asymmetric unit.
Rao M Uppu +4 more
doaj +1 more source
Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis [PDF]
, 2013 Funding This study was funded by the Medical Research Council (Grant number G0800149). Research material from this study is not available. Acknowledgement We are very grateful to Dr Robin A.J. Smith, Department of Chemistry, University of Otago, Dunedin,
Galley, H. F. +3 more
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
JPBI (Jurnal Pendidikan Biologi Indonesia)Given the complexity of cellular respiration, there is a significant need for effective assessment tools that can accurately gauge students’ understanding, identify misconceptions, and provide educators with actionable insights to improve instruction ...
John Daryl C. Bace +4 more
doaj +1 more source
The role of EGFR double minutes in modulating the response of malignant gliomas to radiotherapy. [PDF]
, 2017 EGFR amplification in cells having double minute chromosomes (DM) is commonly found in glioblastoma multiforme (GBM); however, how much it contributes to the current failure to treat GBM successfully is unknown.
Atkin, Naomi +16 more
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Cellular respiration catalyses proto-respiration, proto-respiration catalyses photosynthesis
, 2020 One thing glucose is really good at is reacting with hydroxyl radicals. These form from hydroxide ions stored in protoplasm gel, hydrated potassium hydroxide. Glucose may be a catalyst for proto-respiration, tipping water-oxygen redox balance in favour of degradation of water.
openaire +1 more source
DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling
FEBS Open Bio, EarlyView.Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang +7 more
wiley +1 more source
Methylome and Epialleles in Rice Epilines Selected for Energy Use Efficiency
Agronomy, 2018 Epigenetics offers important opportunities in breeding to improve the potential yield in a wide variety of crops. Starting from a pure breeder seed lot of a rice (Oryza sativa ssp.
Martin Schmidt +8 more
doaj +1 more source