Results 41 to 50 of about 312,550 (342)

Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function [PDF]

, 2014
The time-keeping properties bestowed by oscillatory behavior on functional rhythms represent an evolutionarily conserved trait in living systems. Mitochondrial networks function as timekeepers maximizing energetic output while tuning reactive oxygen ...
Aon, Miguel A., Cortassa, Sonia del Carmen, Kembro, Jackelyn Melissa   +2 more
core   +2 more sources

Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells. [PDF]

, 2017
Metformin is a widely used agent for the treatment of diabetes and infertility, however, it has been found to have anti-cancer effects in a variety of malignancies including high grade serous ovarian cancer (HGSC).
Aspuria, Paul-Joseph P, Hodeib, Melissa, Karlan, Beth Y, Lunt, Sophia Y, Ogrodzinski, Martin P, Reue, Karen, Vergnes, Laurent   +6 more
core   +1 more source

Function of Mitochondrial Stat3 in Cellular Respiration [PDF]

Science, 2009
Cytokines such as interleukin-6 induce tyrosine and serine phosphorylation of Stat3 that results in activation of Stat3-responsive genes. We provide evidence that Stat3 is present in the mitochondria of cultured cells and primary tissues, including the liver and heart. In Stat3 –/– cells,
Węgrzyn, Joanna, Potla, Ramesh, Chwae, Yong-Joon, Sepuri, Naresh B. V., Zhang, Qifang, Koeck, Thomas, Derecka, Marta, Szczepanek, Karol, Szeląg, Magdalena, Górnicka, Agnieszka, Moh, Akira, Moghaddas, Shadi, Chen, Qun, Bobbili, Santha, Cichy, Joanna, Dulak, Józef, Baker, Darren P., Wolfman, Alan, Stuehr, Dennis, Hassan, Medhat O., Fu, Xin-Yuan, Avadhani, Narayan, Drake, Jennifer I., Fawcett, Paul, Lesnefsky, Edward J., Larner, Andrew C.   +25 more
openaire   +3 more sources

Plant-RRBS, a bisulfite and next-generation sequencing-based methylome profiling method enriching for coverage of cytosine positions [PDF]

, 2017
Background: Cytosine methylation in plant genomes is important for the regulation of gene transcription and transposon activity. Genome-wide methylomes are studied upon mutation of the DNA methyltransferases, adaptation to environmental stresses or ...
A Akalin, A Meissner, A Verkest, AJ Bewick, AR Elhamamsy, AR Quinlan, B Langmead, Bram Slabbinck, C Becker, CA Ibarra, Cindy Martens, D Meng, D Pignatta, EJ Finnegan, F Johannes, Frederik Coppens, G Gremme, H Parkinson, H Saze, H Schöb, H Stroud, H Zhang, H-Q Wang, HJ Xie, International Rice Genome Sequencing Project, J Du, J Yu, JI Gent, K Manning, K Okonechnikov, M Block De, M Block De, M Choi, M Hauben, M Schmidt, Magdalena Woloszynska, Marc De Block, Martin Schmidt, MD Schultz, MG Murray, Michiel Van Bel, Mieke Van Lijsebettens, P Cubas, PF Gugger, PS Schnable, R Lister, RJ Schmitz, SE Jacobsen, SJ Cokus, T-F Hsieh, The Arabidopsis Genome Initiative, TJ Treangen, TP Gurp van, W Guo, X Cao, X Chen, X Li, X Wang, X Zhang, ZD Smith, ZL Liu   +60 more
core   +3 more sources

Early pH Changes in Musculoskeletal Tissues upon Injury-Aerobic Catabolic Pathway Activity Linked to Inter-Individual Differences in Local pH [PDF]

, 2020
Local pH is stated to acidify after bone fracture. However, the time course and degree of acidification remain unknown. Whether the acidification pattern within a fracture hematoma is applicable to adjacent muscle hematoma or is exclusive to this ...
Berkmann, Julia C., Duda, Georg N., Ellinghaus, Agnes, Lippens, Evi, Martin, Aaron X. Herrera, Schell, Hanna, Schlundt, Claudia, Schmidt-Bleek, Katharina, Tsitsilonis, Serafeim   +8 more
core   +2 more sources

Mapping mitochondrial aging

eLife
Measuring mitochondrial respiration in frozen tissue samples provides the first comprehensive atlas of how aging affects mitochondrial function in mice.
Alessandro Bitto
doaj   +1 more source

Thyroid thermogenesis in adult rat hepatocytes in primary monolayer culture: direct action of thyroid hormone in vitro. [PDF]

, 1979
We have studied the effect of 3,5,3'-triiodothyronine (T3) on the respiration of adult rat hepatocytes in primary monolayer culture prepared from hypothyroid rat liver. After addition of T3 to the culture medium at a concentration of 2 x 10(-7) M, oxygen
Bissell, DM, Edelman, IS, Ismail-Beigi, F   +2 more
core   +2 more sources

Hyperglycemia induced damage to mitochondrial respiration in renal mesangial and tubular cells: Implications for diabetic nephropathy

Redox Biology, 2016
Damage to renal tubular and mesangial cells is central to the development of diabetic nephropathy (DN), a complication of diabetes which can lead to renal failure.
Anna Czajka, Afshan N. Malik
doaj   +1 more source

The utility of the nitric oxide electrochemical sensor in biomedical research [PDF]

, 2003
In recent years World Precision Instruments Inc. (WPI) produced for commercial use a selective and sensitive electrochemical sensor for the detection of the important biological free radical nitric oxide (NO).
Clark, JB, Hurst, RD
core   +2 more sources

Understanding Cellular Respiration through Simulation Using Lego^® as a Concrete Dynamic Model

Education Sciences, 2019
Out of all the complex systems in science education curricula, cellular respiration is considered to be one of the most complex and abstract processes.
Michiel Dam, Koen Ottenhof, Carla Van Boxtel, Fred Janssen   +3 more
doaj   +1 more source