Results 171 to 180 of about 2,335,939 (309)

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Novel BODIPY-Loaded Liposomes Enhance Cellular Uptake and PDT Efficacy in 2D and 3D Models. [PDF]

Pharmaceutics
Randisi F, Malacarne MC, Milano F, Cappon L, De Leo V, Marras E, Odorico D, Caruso E, Gariboldi MB.   +8 more
europepmc   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Cellular Uptake of Nanoparticles by Sonoporation

, 2017
Encapsulation of anti-cancer drugs in nanoparticles (NPs) can solve many of the problems and side-effects related to cancer treatment today. By exposing micrometer-sized gas-filled bubbles to ultrasound, cellular uptake of NPs can be enhanced through a ...
Hanstad, Sigurd
core  

Cellular Uptake, Intracellular Fate, and Cytotoxicity of Micro- and Nanoparticulate Nickel Substances in Human Lung Cells. [PDF]

Chem Res Toxicol
Karlsson HL, Arora A, Herting G, Path L, Buxton S, Lyons-Darden T, Odnevall I.   +6 more
europepmc   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Apolipoprotein E3-mediated cellular uptake of reconstituted high-density lipoprotein bearing core 3, 10, or 17 nm hydrophobic gold nanoparticles

, 2017
Skylar T Chuang, Young-Seok Shon, Vasanthy Narayanaswami Department of Chemistry and Biochemistry, California State University Long Beach, Long Beach, CA, USA Abstract: We have developed a high-density lipoprotein (HDL)-based platform for transport and
Chuang ST, Narayanaswami V, Shon YS
core  

Quantifying Cellular Uptake of Nanoplastics <i>In Vitro</i>: A Workflow for Fluorescently Labeled Nanosized Polystyrene Particles. [PDF]

ACS Omega
Kirchner MJ, Bennet F, Duijndam AJA, Meirer F, Laforsch C, Roloff A.   +5 more
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Upconversion Colloid for Tracking Cellular Uptake of Nanoparticles. [PDF]

Int J Mol Sci
Nahorniak M, Horák D, Liebl D, Mareková D, Machová Urdzíková L, Macková H, Prokšová P, Benda A.   +7 more
europepmc   +1 more source