Results 171 to 180 of about 3,521 (218)

REV-ERBs negatively regulate mineralization of the cementoblasts

Biochemical and Biophysical Research Communications, 2022
The role of circadian clock in cementogenesis is unclear. This study examines the role of REV-ERBs, one of circadian clock proteins, in proliferation, migration and mineralization of cementoblasts to fill the gap in knowledge.Expression pattern of REV-ERBα in cementoblasts was investigated in vivo and in vitro. CCK-8 assay, scratch wound healing assay,
Liangliang Fu, Min Wang, Guixin Zhu, Zifan Zhao, Huifang Sun, Zhengguo Cao, Haibin Xia   +6 more
openaire   +2 more sources

Tet methylcytosine dioxygenase 1 modulates Porphyromonas gingivalis–triggered pyroptosis by regulating glycolysis in cementoblasts

Annals of the New York Academy of Sciences, 2023
Porphyromonas gingivalis is involved in the pathogenesis of multiple polymicrobial biofilm–induced inflammatory diseases, including apical periodontitis, and it triggers pyroptosis accompanied by robust inflammatory responses.
Yan Peng, Huiyi Wang, Xin Huang, Heyu Liu, Junhong Xiao, Chuang Wang, Li Ma, Xiaoxuan Wang, Z. Cao   +8 more
semanticscholar   +1 more source

M2 macrophages with inflammation tropism facilitate cementoblast mineralization

Journal of Periodontology, 2022
AbstractBackgroundCementum regeneration was regarded as the critical goal for periodontal regeneration, and M2 macrophage‐based therapy was expected to be a promising strategy. However, little is known about the effects of M2 macrophages on cementoblast mineralization and tropism, especially under inflammation.
Xin, Huang, Xiaoxuan, Wang, Li, Ma, Huiyi, Wang, Yan, Peng, Heyu, Liu, Junhong, Xiao, Zhengguo, Cao   +7 more
openaire   +2 more sources

Glycometabolic reprogramming in cementoblasts: A vital target for enhancing cell mineralization

The FASEB Journal, 2023
Cementum, a constituent part of periodontal tissues, has important adaptive and reparative functions. It serves to attach the tooth to alveolar bone and acts as a barrier delimit epithelial growth and bacteria evasion.
Huiyi Wang, Yan Peng, Xin Huang, Junhong Xiao, Li Ma, Heyu Liu, Hantao Huang, Zhengkun Yang, Chuang Wang, Xiaoxuan Wang, Z. Cao   +10 more
semanticscholar   +1 more source

CD40-CD40 ligand interaction between periodontal ligament cells and cementoblasts enhances periodontal tissue remodeling in response to mechanical stress.

Journal of Periodontal Research, 2023
OBJECTIVE We analyzed the localization and expression of Cluster of differentiation 40 ligand (CD40L) in murine periodontal tissue applied with the orthodontic force to determine the CD40L-expressing cells under mechanical stress.
Yu Yamamoto, C. Fujihara, T. Nantakeeratipat, M. Matsumoto, Takahiro Noguchi, M. Kitagawa, Satoru Yamada, Takashi Takata, Hideki Kitaura, Shinya Murakami   +9 more
semanticscholar   +1 more source

The long non-coding RNA, miRNA and mRNA landscapes of cementoblasts during cementogenesis.

Orthodontics & craniofacial research, 2023
OBJECTIVE Stimulation of cementogenesis is essential to cementum regeneration and root restoration. Long non-coding RNAs (lncRNAs) participate in the regulatory networks of periodontal regeneration processes.
Yingying Zhang, Yiping Huang
semanticscholar   +1 more source

Osteoprotegerin Promotes Cementoblastic Activity of Murine Cementoblast Cell Line in vitro.

The Chinese journal of dental research, 2016
To investigate the effect of osteoprotegerin (OPG) on the cementoblastic activity of a clonal population of immortalised murine cementoblasts (OCCM-30) in vitro.OCCM-30 cells were transiently transfected with the mouse OPG using the Avalanche transfection reagent.
Ying Ying, Zhang, Hua Xiang, Zhao, Zhi Bin, Chen, Jiu Xiang, Lin, Yan, Liu   +4 more
openaire   +2 more sources

Activation of periodontal ligament cell cytodifferentiation by juxtacrine signaling from cementoblasts.

The Journal of Periodontology, 2023
BACKGROUND New cementum forms from existing cementum during periodontal tissue regeneration, indicating that cementoblasts may interact with progenitor cells in the periodontal ligament to enhance cementogenesis. However, the molecular mechanisms of this
K. Sawada, Junpei Shimomura, M. Takedachi, M. Murata, C. Morimoto, K. Kawasaki, K. Kawakami, Tomoaki Iwayama, Shinya Murakami   +8 more
semanticscholar   +1 more source

Should Cementoblasts Express Alkaline Phosphatase Activity? Preliminary Study of Rat Cementoblasts In Vitro

Journal of Periodontology, 1999
Background: A well‐characterized cell culture model for cementoblasts is essential to understand the mechanisms of periodontal ligament (PDL) reattachment and regeneration. Whether cementoblasts express alkaline phosphatase (ALP) activity in vivo and in vitro remains to be determined.Methods: Using a 2‐step method of enzyme digestion/explant culture ...
J, Gao, A L, Symons, H, Haase, P M, Bartold   +3 more
openaire   +2 more sources

Inactivation of Sufu in cementoblasts accelerates external tooth root resorption

Journal of Cellular Physiology, 2023
Cementum has been empirically regarded as an antiresorptive barrier against tooth roots. However, little is known about the factors of homeostasis and resistant mechanisms of tooth roots against resorption.
Hwajung Choi, Liu Yang, Yudong Liu, J. Jeong, E. Cho   +4 more
semanticscholar   +1 more source