Results 31 to 40 of about 23,277,623 (249)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman +9 more
wiley +1 more source
A Residual Control Chart Based on Convolutional Neural Network for Normal Interval-Censored Data
MathematicsTo reduce reliability testing time, experiments are often terminated at a predetermined time, producing right-censored lifetime data. Alternatively, when test samples are inspected at fixed intervals, failures are only observed within these intervals ...
Pei-Hsi Lee
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Outcomes in relapsed or refractory pediatric and AYA bone sarcomas remain poor, and the impact of early referral to specialized sarcoma centers on survival is unclear. Early centralization of care may improve local and systemic treatment quality, but evidence in this population is limited.
Justyna Antoniuk‐Majchrzak +9 more
wiley +1 more source
Accelerated hazards model and its extensions for interval-censored data
, 2022 Semiparametric regression analysis of interval-censored data are often performed under popular models, such as the Cox proportional hazards, proportional odds and accelerated failure time models.
Xiang, Liming
core +1 more source
Tratamento de dados censurados em estudos ambientais
Química Nova, 2014 Due to the inherent limitations of the analytical methods of measurement, environmental exposure data often present observations described as below a certain detection limit, also called left-censored data. Censored data directly interferes in almost all
Cristiano Christofaro +1 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
Fundamental ResearchSurvival analysis is a critical tool for cancer research, yet handling censored data remains challenging due to supervision bias and inaccurate hazard estimates.
Xiu-Shen Wei +6 more
doaj +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Left‑Censored Samples from Skewed Distributions: Statistical Inference and Applications
Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2018 Left‑censored data occur frequently in many areas. At present, researchers pay attention to skewed censored distributions more frequently. This paper deals with statistical inference of type I multiply left‑censored Weibull and exponential distributions.
Michal Fusek, Jaroslav Michálek
doaj +1 more source