Results 41 to 50 of about 95,030 (266)
Enhancing uncertainty quantification in drug discovery with censored regression labels
Artificial Intelligence in the Life SciencesIn the early stages of drug discovery, decisions regarding which experiments to pursue can be influenced by computational models for quantitative structure–activity relationships (QSAR).
Emma Svensson +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Censored Bimodal Symmetric-Asymmetric Alpha-Power Model
Revista Colombiana de Estadística, 2013 We introduce the censored bimodal symmetric-asymmetric alpha-power models to adjust censored data with bimodality and high levels of skewness and kurtosis. The moments corresponding are computed, the maximum likelihood estimation for the model parameters
HUGO S. SALINAS +2 more
doaj
Checking semiparametric transformation models with censored data [PDF]
Biostatistics, 2011 Semiparametric transformation models provide a very general framework for studying the effects of (possibly time-dependent) covariates on survival time and recurrent event times. Assessing the adequacy of these models is an important task because model misspecification affects the validity of inference and the accuracy of prediction.
Li, Chen, D Y, Lin, Donglin, Zeng
openaire +2 more sources
Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi +19 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Intravenous thrombolysis (IVT) before thrombectomy for ischemic stroke may alter clot structure and procedural performance. We investigated how IVT relates to thrombectomy metrics across stroke etiologies. Methods We performed a time‐to‐event analysis of consecutive patients with anterior circulation large vessel occlusion (acLVO ...
Annahita Sedghi +8 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have demonstrated significant weight‐reducing effects and may offer benefits in idiopathic intracranial hypertension (IIH); however, recent concerns about the risk of non‐arteritic anterior ischemic optic neuropathy (NAION) have emerged.
Faisal A. Al‐Harbi +9 more
wiley +1 more source
A-Spline Regression for Fitting a Nonparametric Regression Function with Censored Data
Stats, 2020 This paper aims to solve the problem of fitting a nonparametric regression function with right-censored data. In general, issues of censorship in the response variable are solved by synthetic data transformation based on the Kaplan–Meier estimator in the
Ersin Yılmaz +2 more
doaj +1 more source
The Log-Beta Generalized Half-Normal Regression Model [PDF]
Journal of Statistical Theory and Applications (JSTA), 2013 We introduce a log-linear regression model based on the beta generalized half-normal distribution (Pescim et al., 2010).We formulate and develop a log-linear model using a new distribution so-called the log-beta general- ized half normal distribution.We ...
Rodrigo R. Pescim +4 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou +16 more
wiley +1 more source