Results 1 to 10 of about 25,475 (182)

[Application of sequential methods in randomized clinical trials with censored response criteria].

Revue d'epidemiologie et de sante publique, 1987
In randomized clinical trials with a censored response criterion, it is common practice to perform interim analyses, especially for reasons of medical ethics. Sequential methods allow for repeated testing. Three sequential methods are well adapted to censored data: the group sequential analysis, the sequential probability ratio test and the triangular ...
J, Benichou, C, Chastang
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Design aspects for clinical trials with repeated measures in the presence of informative censoring

Journal of Statistical Planning and Inference, 1994
Abstract Likelihood-based procedures derived under the linear random effects model and distribution-free tests obtained by combining marginal U statistics as well as by ranking the individual effects are reviewed for clinical trials with repeated measures.
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A Bayesian Approach to Weibull Survival Model for Clinical Randomized Censoring Trial Based on MCMC Simulation

2008 2nd International Conference on Bioinformatics and Biomedical Engineering, 2008
Survival analysis for randomized censored data is common in clinical trial. Among various survival models proposed to deal with such censoring, Weilbull regression model is widely used as one of accelerated failure time models, because it's flexible to suit different applications. It's well known that Bayesian analysis has the advantage in dealing with
Xujie Zhao, Chao Yu, Hengqing Tong
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Clinical trials in psychiatry: should protocol deviation censor patient data?

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1992
Clinical trials methodologists recommend counting all events regardless of adherence to protocol and comparing originally randomized groups. This strict "intent-to-treat" policy implies availability and use of outcome measures taken regardless of adherence to treatment protocol. However, outcome measurement in psychiatry requires the cooperation of the
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Making Sense of Clinical Trial Data: Is Inverse Probability of Censoring Weighted Analysis the Answer to Crossover Bias?

Journal of Clinical Oncology, 2012
Ideally, therapeutic interventions are evaluated through randomized clinical trials. These trials are commonly analyzed with an intent-to-treat (ITT) approach, whereby patients are analyzed in their assigned treatment group regardless of actual treatment received.
Mothaffar, Rimawi, Susan G, Hilsenbeck
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Empirical estimation of life expectancy from large clinical trials: Use of left‐truncated, right‐censored survival analysis methodology

Statistics in Medicine, 2008
AbstractIn the current era of ever‐increasing health care costs, economic analyses are an essential component in the comprehensive evaluation of new medical interventions. Cost‐effectiveness analysis (CEA)—the most common form of economic analysis used in medicine—aids policy‐makers in determining how to allocate finite health care dollars among ...
Charlotte L, Nelson, Jie L, Sun, Anastasios A, Tsiatis, Daniel B, Mark   +3 more
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Statistical Properties and Use of Sequential Methods in Randomized Clinical Trials when the Response Criterion Is Censored

1988
In diseases such as cancer and more generally chronic conditions randomized clinical trials often use time to occurrence of a given event as the main response criterion. Survival time, i. e., time to death, is the most widely used of such criteria. Other examples include disease-free interval, duration of a remission period, or time to occurrence of a ...
J, Bénichou, C, Chastang
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Efficient Estimation of Mann–Whitney-Type Effect Measures for Right-Censored Survival Outcomes in Randomized Clinical Trials

Statistics in Biosciences, 2019
Mann–Whitney-type effect measures are clinically relevant, easy to interpret, and readily applicable to a wide range of study settings. This article considers estimation of such effect measures in randomized clinical trials where the outcome variable is a survival time subject to independent censoring (within each treatment group).
Zhiwei Zhang, Wei Li, Hui Zhang
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Sensitivity analyses of time-to-event data with possibly informative censoring for confirmatory clinical trials

2012
We presents a multiple imputation method for sensitivity analysis of continuous time-to-event data with possibly informative censoring. The imputed time for censored values is drawn from the failure time distribution conditional on the time of follow-up discontinuation. A variety of specifications regarding the post-withdrawal tendency of having events
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Properties of three sequential methods in randomized clinical trials with a censored response criterion

Controlled Clinical Trials, 1986
Jacques Benichou, Claude Chastang
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