Results 91 to 100 of about 25,475 (182)

Experimental hypothermia by cold air: a randomized, double-blind, placebo-controlled crossover trial

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Background Accidental hypothermia is associated with high morbidity and mortality. Research on treatment strategies for accidental hypothermia is complicated by the low incidence and heterogeneous patient population.
Ane M. Helland, Sigurd Mydske, Jörg Assmus, Guttorm Brattebø, Øystein Wiggen, Haakon K. Kvidaland, Øyvind Thomassen   +6 more
doaj   +1 more source

Is inverse probability of censoring weighting a safer choice than per-protocol analysis in clinical trials?

Statistical Methods in Medical Research
Deviation from the treatment strategy under investigation occurs in many clinical trials. We term this intervention deviation. Per-protocol analyses are widely adopted to estimate a hypothetical estimand without the occurrence of intervention deviation. Per-protocol by censoring is prone to selection bias when intervention deviation is associated with
Xuan, J., Mt-Isa, S., Latimer, N., Bell Gorrod, H., Malbecq, W., Vandormael, K., Yorke-Edwards, V., White, I.R.   +7 more
openaire   +3 more sources

Clinical Trial Censoring [PDF]

, 2020
openaire   +1 more source

A Deep Learning–Enabled Workflow to Estimate Real-World Progression-Free Survival in Patients With Metastatic Breast Cancer: Study Using Deidentified Electronic Health Records

JMIR Cancer
BackgroundProgression-free survival (PFS) is a crucial endpoint in cancer drug research. Clinician-confirmed cancer progression, namely real-world PFS (rwPFS) in unstructured text (ie, clinical notes), serves as a reasonable surrogate for real-world ...
Gowtham Varma, Rohit Kumar Yenukoti, Praveen Kumar M, Bandlamudi Sai Ashrit, K Purushotham, C Subash, Sunil Kumar Ravi, Verghese Kurien, Avinash Aman, Mithun Manoharan, Shashank Jaiswal, Akash Anand, Rakesh Barve, Viswanathan Thiagarajan, Patrick Lenehan, Scott A Soefje, Venky Soundararajan   +16 more
doaj   +1 more source

Addressing treatment switching in the ALTA-1L trial with g-methods: exploring the impact of model specification

BMC Medical Research Methodology
Background Treatment switching in randomized clinical trials introduces challenges in performing causal inference. Intention To Treat (ITT) analyses often fail to fully capture the causal effect of treatment in the presence of treatment switching ...
Amani Al Tawil, Sean McGrath, Robin Ristl, Ulrich Mansmann   +3 more
doaj   +1 more source

Reconstructing Pseudo Individual Patient-Level Data From Published Survival Curves in Cardiovascular Trials. [PDF]

J Am Coll Cardiol
Tong G, Li F.
europepmc   +1 more source

A note on rank-preserving structural failure time models to account for crossover. [PDF]

Clin Trials
Torres-Saavedra PA, Freidlin B, Jeong JH, Korn EL.   +3 more
europepmc   +1 more source

Reassessment of the Collaborative Normal-Tension Glaucoma Study: Statistical Evidence and Implications for Current Management. [PDF]

Ophthalmol Ther
Killer HE, Pircher A, Stekhoven DJ.
europepmc   +1 more source

While-alive regression analysis of composite survival endpoints. [PDF]

Biostatistics
Fang X, Uno H, Li F.
europepmc   +1 more source

Impact and effective management of nausea/vomiting on patients treated with zolbetuximab + chemotherapy: insights from the phase III SPOTLIGHT and GLOW studies. [PDF]

ESMO Open
Shitara K, Smyth E, Lordick F, Pophale R, Matney C, Matsangou M, Gourgioti G, Oh M, Ranganath R, Klempner SJ.   +9 more
europepmc   +1 more source