A Two-Step Variable Selection Strategy for Multiply Imputed Survival Data Using Penalized Cox Models. [PDF]
Yang Q, Luo B, Yu C, Halabi S.
europepmc +1 more source
The impact of analysis methodology details on invasive breast cancer-free survival in randomized clinical trials. [PDF]
Hlauschek D, Fesl C, Gnant M.
europepmc +1 more source
Penalized Variable Selection for Joint AFT Random-Effect Model With Clustered Competing-Risks Data. [PDF]
Hao L, Do Ha I.
europepmc +1 more source
Causal inference with right censored survival data from randomized clinical trials
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Two-Stage Estimation of Overall Survival in the Phase 3 CheckMate 9ER Trial, Adjusting for the Impact of Subsequent Therapy. [PDF]
Grimm MO +7 more
europepmc +1 more source
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Nonignorable censoring in randomized clinical trials
Clinical Trials, 2005Background In a clinical trial, survival may be censored by the end of the study, especially for subjects who enter later in the enrollment period. If there is a trend toward better survival over time then longer survivors experience shorter censoring times (heavier censoring).
Jiameng, Zhang, Daniel F, Heitjan
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Sample Size Reestimation for Clinical Trials With Censored Survival Data
Journal of the American Statistical Association, 2003A flexible design with updating of sample size in clinical trials is proposed for censored survival data. Patients enter trials serially and are subject to random loss to follow-up. The statistical inference is based on a weighted average of the linear rank statistics, where the weight function at each look depends on prior observed data.
Shen Y., Cai J.
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Statistical inference on censored data for targeted clinical trials under enrichment design
Pharmaceutical Statistics, 2013For the traditional clinical trials, inclusion and exclusion criteria are usually based on some clinical endpoints; the genetic or genomic variability of the trial participants are not totally utilized in the criteria. After completion of the human genome project, the disease targets at the molecular level can be identified and can be utilized for the ...
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Failure time data subject to various types of censoring commonly arise in epidemiological and biomedical studies. Motivated by an AIDS clinical trial, we consider regression analysis of failure time data that include exact and left‐, interval‐, and/or right‐censored observations, which are often referred to as partly interval‐censored failure time data.
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Summary. AIDS Clinical Trial Group (ACTG) randomized trial 021 compared the effect of bactrim versus aerosolized pentamidine (AP) as prophylaxis therapy for pneumocystis pneumonia (POP) in AIDS patients. Although patients randomized to the bactrim arm experienced a significant delay in time to POP, the survival experience in the two arms was not ...
Robins, James M., Finkelstein, Dianne M.
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