Results 31 to 40 of about 25,475 (182)

Joint Modelling of Longitudinal Outcome and Interval-Censored Competing Risk Dropout in a Schizophrenia Clinical Trial [PDF]

Journal of the Royal Statistical Society Series A: Statistics in Society, 2011
SummaryThe ‘Clinical antipsychotic trials in intervention effectiveness’ study was designed to evaluate whether there were significant differences between several antipsychotic medications in effectiveness, tolerability, cost and quality of life of subjects with schizophrenia.
Ralitza, Gueorguieva, Robert, Rosenheck, Haiqun, Lin   +2 more
openaire   +2 more sources

Target trial emulation with multi-state model analysis to assess treatment effectiveness using clinical COVID-19 data

BMC Medical Research Methodology, 2023
Background Real-world observational data are an important source of evidence on the treatment effectiveness for patients hospitalized with coronavirus disease 2019 (COVID-19).
Oksana Martinuka, Derek Hazard, Hamid Reza Marateb, Camille Maringe, Marjan Mansourian, Manuel Rubio-Rivas, Martin Wolkewitz   +6 more
doaj   +1 more source

Multiple Imputation Approaches for Missing Time-to-Event Outcomes with Informative Censoring: Practical Considerations from a Simulation Study Based on Real Data

Epidemiology, Biostatistics and Public Health
Missing outcomes data represent a common threat to the validity and robustness of clinical trials with time-to-event outcomes. Recent extensions of multiple imputations (MI), namely controlled-MI, have been introduced as a viable approach for ...
Andrea Bellavia, Min Guo, Sabina Murphy
doaj   +1 more source

Bernoulli-exponential survival model for estimating proportions in randomised controlled trials with dropouts

Recent Advances in Natural Sciences
Randomised controlled trials often experience dropouts, especially in multi-stage designs where participants must meet induction-phase eligibility requirements before progressing to the main study.
Ekele Alih
doaj   +1 more source

Effectiveness of remdesivir in hospitalized nonsevere patients with COVID-19 in Japan: A large observational study using the COVID-19 Registry Japan

International Journal of Infectious Diseases, 2022
Objectives: To evaluate the effectiveness of remdesivir in the early stage of nonsevere COVID-19. Although several randomized controlled trials have compared the effectiveness of remdesivir with that of a placebo, there is limited evidence regarding its ...
Shinya Tsuzuki, Kayoko Hayakawa, Yukari Uemura, Tomohiro Shinozaki, Nobuaki Matsunaga, Mari Terada, Setsuko Suzuki, Yusuke Asai, Koji Kitajima, Sho Saito, Gen Yamada, Taro Shibata, Masashi Kondo, Kazuo Izumi, Masayuki Hojo, Tetsuya Mizoue, Kazuhisa Yokota, Fukumi Nakamura-Uchiyama, Fumitake Saito, Wataru Sugiura, Norio Ohmagari   +20 more
doaj   +1 more source

Modeling observations with a detection limit using a truncated normal distribution with censoring

BMC Medical Research Methodology, 2020
Background When data are collected subject to a detection limit, observations below the detection limit may be considered censored. In addition, the domain of such observations may be restricted; for example, values may be required to be non-negative ...
Justin R. Williams, Hyung-Woo Kim, Catherine M. Crespi   +2 more
doaj   +1 more source

Efficacy and Tolerability of Topotecan/Cyclophosphamide/Dinutuximab in Relapsed and Refractory High‐Risk Neuroblastoma: A Multi‐Institutional Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Chemoimmunotherapy with irinotecan, temozolomide, and dinutuximab (I/T/DIN) has emerged as first‐line therapy for relapsed/refractory (r/r) high‐risk neuroblastoma (HRNB) in North America. Topotecan and cyclophosphamide (T/C) are often used in combination with dinutuximab in the setting of lack of response, progression, or incomplete ...
Benjamin J. Lerman, Madeleine King, Rajen Mody, Sara‐Jane Onyeama, Araz Marachelian, Thomas Cash, Sara M. Federico, Meaghan Granger, Ami V. Desai, Suzanne Shusterman, Jennifer H. Foster, Elizabeth Sokol, Chelsee Greer, Keri Streby, Holly J. Meany, Kieuhoa T. Vo, Margaret E. Macy, Rochelle Bagatell   +17 more
wiley   +1 more source

Reliability Inference for ZLindley Models Under Improved Adaptive Progressive Censoring: Applications to Leukemia Trials and Flood Risks

Mathematics
Modern healthcare and engineering both rely on robust reliability models, where handling censored data effectively translates into longer-lasting devices, improved therapies, and safer environments for society.
Refah Alotaibi, Ahmed Elshahhat
doaj   +1 more source

Dealing with indeterminate outcomes in antimalarial drug efficacy trials: a comparison between complete case analysis, multiple imputation and inverse probability weighting

BMC Medical Research Methodology, 2019
Background Antimalarial clinical efficacy studies for uncomplicated Plasmodium falciparum malaria frequently encounter situations in which molecular genotyping is unable to discriminate between parasitic recurrence, either new infection or recrudescence.
Prabin Dahal, Kasia Stepniewska, Philippe J. Guerin, Umberto D’Alessandro, Ric N. Price, Julie A. Simpson   +5 more
doaj   +1 more source

Alveolar Soft Part Sarcoma in Pediatric and Young Adult Patients: A Report From the Children's Oncology Group Study ARST0332

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma occurring most commonly in adolescence and young adulthood. Methods We present the clinical characteristics, treatments, and outcomes of patients with newly diagnosed ASPS enrolled on the Children's Oncology Group study ARST0332.
Jacquelyn N. Crane, Wei Xue, Amira Qumseya, Thomas Scharschmidt, Kathryn R. Tringale, Oscar Lopez Nunez, Jiaqi Hu, Donald A. Barkauskas, Rajkumar Venkatramani, Sheri L. Spunt, Aaron R. Weiss, Noah C. Federman   +11 more
wiley   +1 more source