Results 251 to 260 of about 16,760,378 (317)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Time dependent outcomes modeling in a real-world analysis of the molecular tumor board at University Cancer Center Hamburg (2016-2022). [PDF]

Oncologist
Velthaus-Rusik JL, Weller JF, Hoshaber M, Schmidt B, Albers-Leischner C, Kriegs M, Loges S, Bartels S, Schlüter C, Simon R, Volk AE, Kubisch C, Ückert F, Riemann L, Weisel K, von Amsberg G, Alsdorf W, Bokemeyer C, Christopeit M.   +18 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Publisher Correction: Mutant KRAS vaccine with dual checkpoint blockade in resected pancreatic cancer: a phase I trial. [PDF]

Nat Commun
Huff AL, Haldar SD, Girgis AA, Wang HH, Danilova L, Heumann T, Berg M, Wang Y, Andaloori L, Hernandez A, Longway G, Barrett B, Zhu Z, Davis-Marcisak E, Thoburn C, Leatherman J, Mitchell S, Lee JW, Shu DH, Konig MF, Mog BJ, Montagne J, Coyne EM, Bever K, Baretti M, Yarchoan M, Anders RA, Kagohara LT, Laheru D, Thomas AM, Durham J, Nauroth JM, Lu J, Wang H, Fertig EJ, Ho WJ, Azad NS, Jaffee EM, Zaidi N.   +38 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Author Correction: Gate tuning of coupled electronic and structural phase transition in atomically thin Ta₂NiSe₅. [PDF]

Nat Commun
Wei K, Luo Y, Watanabe K, Taniguchi T, Guo Y, Xi X.   +5 more
europepmc   +1 more source

Correction: Anti-lipid IgG antibodies are produced via germinal centers in a murine model resembling human lupus. [PDF]

Front Immunol
Wong-Baeza C, Reséndiz-Mora A, Donis-Maturano L, Wong-Baeza I, Zárate-Neira L, Yam-Puc JC, Calderón-Amador J, Medina Y, Wong C, Baeza I, Flores-Romo L.   +10 more
europepmc   +1 more source

Author Correction: Structure and mechanism of antiphage retron Eco2. [PDF]

Nat Struct Mol Biol
Jasnauskaitė M, Juozapaitis J, Liegutė T, Grigaitis R, Skorupskaitė A, Steinchen W, Mikšys A, Truncaitė L, Kazlauskaitė K, Torres Jiménez MF, Khochare S, Dudas G, Bange G, Malinauskaitė L, Songailienė I, Pausch P.   +15 more
europepmc   +1 more source

Enable preclinical, high-precision image-guided radiotherapy research with a stand-alone small animal IGRT system. [PDF]

Med Phys
Deng W, Han D, Byrne KE, Bhandary B, Jiang K, Poirier YP, Mossahebi S, Xu J, Shukla H, Sawant A.   +9 more
europepmc   +1 more source

Author Correction: HDAC6 facilitates LUAD progression by inducing EMT and enhancing macrophage polarization towards the M2 phenotype. [PDF]

NPJ Precis Oncol
Jiang Y, Zhang J, Yu J, Luo W, Du Q, Liu W, Xu Q, Li X, Liu H, Huang D, Qin T.   +10 more
europepmc   +1 more source