Results 51 to 60 of about 125,632 (233)

The Academic Medical Center Linear Disability Score (ALDS) item bank: item response theory analysis in a mixed patient population

open access: yesHealth and Quality of Life Outcomes, 2005
Background Currently, there is a lot of interest in the flexible framework offered by item banks for measuring patient relevant outcomes. However, there are few item banks, which have been developed to quantify functional status, as expressed by the ...
Vermeulen Marinus   +6 more
doaj   +1 more source

'You're not just a medical professional': Exploring paramedic experiences of overdose response within Vancouver's downtown eastside.

open access: yesPLoS ONE, 2020
BackgroundOverdose response has become an increasingly relevant component of paramedic practice, particularly in light of increased opioid overdose globally.
Jordan Williams-Yuen   +4 more
doaj   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

open access: yesFEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Contributions to inflation after euro adoption: the case of Central and Eastern European countries

open access: yesEkonomia i Prawo, 2020
Motivation: Based on theory, the introduction of a single currency should cause a decrease in transaction costs, which in effect should lead to a drop in consumer prices.
Kamil Kotliński
doaj   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

Development of the performance prediction algorithms for cloud services

open access: yesSistemnì Doslìdženâ ta Informacìjnì Tehnologìï, 2018
Main stages of data center service performance prediction were discussed, specifically data monitoring and gathering, calculation and prediction of key indexes and performance index prediction.
Denis O. Zuev   +3 more
doaj   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

open access: yesFEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona   +4 more
wiley   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

open access: yesFEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

Experiencing the education process in physical rehabilitation

open access: yesRevista da Escola de Enfermagem da USP
Objective: To interpret and build a theoretical model of the user’s experience in the education process in physical rehabilitation settings. Method: Qualitative research, based on the Grounded Theory. The setting was a Rehabilitation Center of Rede Lucy
Simone Nunes Pereira   +3 more
doaj   +2 more sources

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