Results 81 to 90 of about 1,085,855 (260)

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi   +26 more
wiley   +1 more source

An institutional history. Note on the Center of Hispanic-American Letters-CELEHIS

open access: yesEstudios de Teoría Literaria, 2016
The note summarizes the origin and development of CELEHIS (Center of Hispanic American Literature), an agency of the Faculty of Humanities, UNMdP. This institutional area dedicated to research arises at the beginning of the democratic opening (1984) and ...
Elisa Calabrese
doaj  

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

Hypertoric category O

open access: yes, 2014
We study the representation theory of the invariant subalgebra of the Weyl algebra under a torus action, which we call a "hypertoric enveloping algebra." We define an analogue of BGG category O for this algebra, and identify it with a certain category of
Braden, Tom   +3 more
core  

Del “instante” y la categoría de lo posible/On the “instant” and thecategory of possibility

open access: yesETD: Educação Temática Digital, 2010
El objeto de este escrito es mostrar posibles articulaciones entre la categoría del instante (Kierkegaard) y algunos aspectos de la teoría de Lacan. Mi reflexión se centrará, principalmente, en los conceptos de “instante”, “angustia” y “mirada”.
Marianella Lorenzo
doaj  

Student Achievement Based on the Use of Scientific Method in the Natural Science Subject in Elementary School

open access: yesJurnal Pendidikan IPA Indonesia, 2019
This research aims at investigating elementary school student achievement based on the use ofscientific method in teaching science from the test item types, as reflected by the item difficulty indexusing the classical test theory (CTT) and modern test ...
B. Subali   +3 more
doaj   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

Monodromy group for a strongly semistable principal bundle over a curve, II

open access: yes, 2006
Let $X$ be a geometrically irreducible smooth projective curve defined over a field $k$. Assume that $X$ has a $k$-rational point; fix a $k$-rational point $x\in X$.
Biswas, Indranil, Parameswaran, A. J.
core   +2 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

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