Results 81 to 90 of about 1,200,985 (247)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Designing a Branding Model for a TV Talk Show with an Emphasis on Ethical & Social Factors [PDF]

International Journal of Ethics and Society, 2022
Background: Today, the influence of the media on the moral relations of individuals at the interpersonal and social level is an important part of the field of social sciences.
Amir Mohammadi, Ali Mohammad Mazidi Sharifabadi, Mohammad Soltanifar   +2 more
doaj  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

S-E-R-V-E a theoretical framework for Christian leadership

Scandinavian Journal for Leadership & Theology
This article introduces a new perspective on Christian leadership. The theoretical framework critically integrates and transforms Gary Yukl’s theory of four meta-categories of leadership.
Karl Inge Tangen
doaj   +3 more sources

Category and Approach of the Study on Nursing

Huli yanjiu, 1998
According to the transition of medicine mode,the modern nursing is translating from the traditional concept of regarding the disease as a center to the holism concept of regarding the patient as a center.This transition makes the nursing function ...
Zhang Yanjing(Beijing Dongcheng Health School, Beijing 100013 China)   +1 more
doaj  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Del “instante” y la categoría de lo posible/On the “instant” and thecategory of possibility

ETD: Educação Temática Digital, 2010
El objeto de este escrito es mostrar posibles articulaciones entre la categoría del instante (Kierkegaard) y algunos aspectos de la teoría de Lacan. Mi reflexión se centrará, principalmente, en los conceptos de “instante”, “angustia” y “mirada”.
Marianella Lorenzo
doaj  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

An institutional history. Note on the Center of Hispanic-American Letters-CELEHIS

Estudios de Teoría Literaria, 2016
The note summarizes the origin and development of CELEHIS (Center of Hispanic American Literature), an agency of the Faculty of Humanities, UNMdP. This institutional area dedicated to research arises at the beginning of the democratic opening (1984) and ...
Elisa Calabrese
doaj  

Student Achievement Based on the Use of Scientific Method in the Natural Science Subject in Elementary School

Jurnal Pendidikan IPA Indonesia, 2019
This research aims at investigating elementary school student achievement based on the use ofscientific method in teaching science from the test item types, as reflected by the item difficulty indexusing the classical test theory (CTT) and modern test ...
B. Subali, K. Kumaidi, N. S. Aminah, B. Sumintono   +3 more
doaj   +1 more source