Results 51 to 60 of about 94,676 (275)
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Moduli of map germs, Thom polynomials and the Green-Griffiths conjecture [PDF]
, 2012 This survey paper is based on my IMPANGA lectures given in the Banach Center, Warsaw in January 2011. We study the moduli of holomorphic map germs from the complex line into complex compact manifolds with applications in global singularity theory and the
Bérczi, Gergely
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Mechanical Entropy and Its Implications
Entropy, 2001 : It is shown that the classical laws of thermodynamics require that mechanical systems must exhibit energy that becomes unavailable to do useful work. In thermodynamics, this type of energy is called entropy.
Pharis E. Williams
doaj +1 more source
A new type of nonsingular black-hole solution in general relativity
, 2014 Certain exact solutions of the Einstein field equations over nonsimply-connected manifolds are reviewed. These solutions are spherically symmetric and have no curvature singularity.
Klinkhamer, F. R.
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Hair in the Back of a Throat: Non-Supersymmetric Multi-Center Solutions from K\"ahler Manifolds
, 2011 We find a class of non-supersymmetric multi-center solutions of the STU model of five-dimensional ungauged supergravity. The solutions are determined by a system of linear equations defined on a four-dimensional K\"ahler manifold with vanishing Ricci ...
Bobev, Nikolay +2 more
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
C^k invariant manifolds for infinite delay
Electronic Journal of Differential Equations, 2019 For a non-autonomous delay difference equation with infinite delay, we construct smooth stable and unstable invariant manifolds for any sufficiently small perturbation of an exponential dichotomy.
Luis Barreira, Claudia Valls
doaj