Results 61 to 70 of about 94,676 (275)

Dynamics in the centre manifold around equilibrium points in periodically perturbed three-body problems [PDF]

open access: yes, 2016
A new application of the parameterization method is pre- sented to compute invariant manifolds about the equilib- rium points of Periodically Perturbed Three-Body Problems ( PPTBP ).
Gomez Muntané, Gerard   +3 more
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Joint Infrared Target Recognition and Segmentation Using a Shape Manifold-Aware Level Set

open access: yesSensors, 2015
We propose new techniques for joint recognition, segmentation and pose estimation of infrared (IR) targets. The problem is formulated in a probabilistic level set framework where a shape constrained generative model is used to provide a multi-class and ...
Liangjiang Yu   +3 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Completeness relation in renormalized quantum systems

open access: yesFrontiers in Physics
In this work, we show that the completeness relation for the eigenvectors, which is an essential assumption of quantum mechanics, remains true if the Hamiltonian, having a discrete spectrum, is modified by a delta potential (to be made precise by a ...
Fatih Erman   +2 more
doaj   +1 more source

Local invariant manifolds for delay differential equations with state space in $C^1((-\infty,0],\mathbb{R}^n)$

open access: yesElectronic Journal of Qualitative Theory of Differential Equations, 2016
Consider the delay differential equation $x'(t)=f(x_t)$ with the history $x_t:(-\infty,0]\to\mathbb{R}^n$ of $x$ at 'time' $t$ defined by $x_t(s)=x(t+s)$. In order not to lose any possible entire solution of any example we work in the Fréchet space $C^1((
Hans-Otto Walther
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Centers on center manifolds in a quadratic system obtained froma scalar third-order differential equation

open access: yesElectronic Journal of Differential Equations, 2011
We give affirmative answers to two questions concerning the existence of centers on local center manifolds at equilibria of a quadratic system in the three dimensional space.
Warley Ferreira da Cunha   +2 more
doaj  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

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