Results 61 to 70 of about 4,711,203 (306)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Kahler manifolds and their relatives [PDF]
, 2010 Let M1 and M2 be two K¨ahler manifolds. We call M1 and M2 relatives if they share a non-trivial K¨ahler submanifold S, namely, if there exist two holomorphic and isometric immersions (K¨ahler immersions) h1 : S → M1 and h2 : S → M2. Moreover, two K¨ahler
Loi, A., Di Scala, Antonio Jose'
core
Center manifolds for nonuniformly partially hyperbolic diffeomorphisms [PDF]
, 2005 We establish the existence of smooth invariant center manifolds for the nonuniformly partially hyperbolic trajectories of a diffeomorphism in a Banach space.
Valls, Claudia, Barreira, Luis
core +1 more source
Mechanical Entropy and Its Implications
Entropy, 2001 : It is shown that the classical laws of thermodynamics require that mechanical systems must exhibit energy that becomes unavailable to do useful work. In thermodynamics, this type of energy is called entropy.
Pharis E. Williams
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Limit theorems for empirical Fréchet means of independent and non-identically distributed manifold-valued random variables [PDF]
, 2011 We prove weak laws of large numbers and central limit theorems of Lindeberg type for empirical centres of mass (empirical Fréchet means) of independent nonidentically distributed random variables taking values in Riemannian manifolds.
Huiling Le +3 more
core +1 more source
C^k invariant manifolds for infinite delay
Electronic Journal of Differential Equations, 2019 For a non-autonomous delay difference equation with infinite delay, we construct smooth stable and unstable invariant manifolds for any sufficiently small perturbation of an exponential dichotomy.
Luis Barreira, Claudia Valls
doaj
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source