Results 131 to 140 of about 3,814,816 (395)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Brightening triplet excitons enable high-performance white-light emission in organic small molecules via integrating n–π*/π–π* transitions

Nature Communications
Luminescent materials that simultaneously embody bright singlet and triplet excitons hold great potential in optoelectronics, signage, and information encryption.
Qing Yang, Xinyi Yang, Yixuan Wang, Yunfan Fei, Fang Li, Haiyan Zheng, Kuo Li, Yibo Han, Takanori Hattori, Pinwen Zhu, Shuaiqiang Zhao, Leiming Fang, Xuyuan Hou, Zhaodong Liu, Bing Yang, Bo Zou   +15 more
doaj   +1 more source

Bipedal robot center of pressure feedback simulation for center of mass learning

IAES International Journal of Robotics and Automation (IJRA)
This research aims to create a walking bipedal robot with center of pressure feedback simulation for the center of mass learning, describe its feasibility for learning, describe students' motivation to learn, and describe students' science literacy after using it.
Afrizal Mayub, Fahmizal Fahmizal, Lazfihma Lazfihma   +2 more
openaire   +1 more source

Reliability, validity, and effectiveness of center of pressure parameters in assessing stabilometric platform in subjects with incomplete spinal cord injury: a serial cross-sectional study

Journal of NeuroEngineering and Rehabilitation, 2014
BackgroundSpinal cord injury (SCI) can damage long tracts, affecting postural stability. Impairments in balance have recently been proposed to be highly predictive of functional recovery in patients with SCI and thus merit evaluation.
F. Tamburella, G. Scivoletto, M. Iosa, M. Molinari   +3 more
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

A distinctive HPHT platform with different types of large-volume press subsystems at SECUF

Matter and Radiation at Extremes
Large-volume presses (LVPs) providing large volumes, liquid media, deformation capability, jump compression, and in situ measurements are in great demand for high-pressure research, particularly in the fields of geoscience, condensed matter physics ...
Yufei Ge, Shuailing Ma, Cun You, Kuo Hu, Chuang Liu, Yixuan Wang, Xinglin Wang, Xinyang Li, Hongyu Li, Qiang Tao, Shuqing Jiang, Lu Wang, Hu Tang, Di Yao, Zhi He, Xinyi Yang, Zhaodong Liu, Qiang Zhou, Pinwen Zhu, Bo Zou, Bingbing Liu, Tian Cui   +21 more
doaj   +1 more source

Improving Access to Home Blood Pressure Monitors at a Federally Qualified Health Center

, 2023
Isha Deshpande, Amrita Kanwar, Kendra Swyers, Aida Garza, Kathryn Litten   +4 more
openalex   +1 more source