Results 51 to 60 of about 1,088,242 (267)
Fault tolerant K-center problems
Theoretical Computer Science, 2000 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Khuller, Samir +2 more
openaire +2 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Darboux integrability and rational reversibility in cubic systems with two invariant straight lines
Electronic Journal of Differential Equations, 2013 We find conditions for a singular point O(0,0) of a center or a focus type to be a center, in a cubic differential system with two distinct invariant straight lines.
Dumitru Cozma
doaj
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Faciliteret Multi-Source Feedback som pædagogisk kompetenceudvikling – et dansk casestudie
Dansk Universitetspaedagogisk Tidsskrift, 2020 De seneste års politiske og institutionelle fokus på kvalitetssikring i undervisningen på de videregående uddannelser har afdækket et behov for at anerkende undervisning på lige fod med forskning.
Iris Maria Pedersen +3 more
doaj
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Optimal algorithms for weighted 1-center problem in deterministic and stochastic tree networks
Alexandria Engineering Journal, 2020 This paper deals with two single facility location problems. The first problem is about the deterministic weighted (DW) 1-center of a deterministic tree network (DTN).
A.W. Aboutahoun, F. El-Safty
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Mathematics, 2020 The capacitated vertex k-center problem receives as input a complete weighted graph and a set of capacity constraints. Its goal is to find a set of k centers and an assignment of vertices that does not violate the capacity constraints.
José Alejandro Cornejo Acosta +3 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source