Results 61 to 70 of about 5,124,705 (288)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Darboux integrability and rational reversibility in cubic systems with two invariant straight lines

open access: yesElectronic Journal of Differential Equations, 2013
We find conditions for a singular point O(0,0) of a center or a focus type to be a center, in a cubic differential system with two distinct invariant straight lines.
Dumitru Cozma
doaj  

Investigation of the adhesive properties of composites based on polyimide varnish and copper oxide, boron nitride and technical diamond powders [PDF]

open access: yesModern Electronic Materials
The article describes the preparing process for composites with a polyimide varnish PILK-2B matrix, which filled with particles of technical diamond, copper oxide, cubic boron nitride and hexagonal boron nitride for use in redistribution layers during ...
Igor A. Belyakov   +5 more
doaj   +3 more sources

Fault tolerant K-center problems

open access: yesTheoretical Computer Science, 2000
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Khuller, Samir   +2 more
openaire   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

open access: yesMolecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor   +2 more
wiley   +1 more source

Faciliteret Multi-Source Feedback som pædagogisk kompetenceudvikling – et dansk casestudie

open access: yesDansk Universitetspaedagogisk Tidsskrift, 2020
De seneste års politiske og institutionelle fokus på kvalitetssikring i undervisningen på de videregående uddannelser har afdækket et behov for at anerkende undervisning på lige fod med forskning.
Iris Maria Pedersen   +3 more
doaj  

Insights into a long life without cancer: The case of the bowhead whale

open access: yesMolecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Optimal algorithms for weighted 1-center problem in deterministic and stochastic tree networks

open access: yesAlexandria Engineering Journal, 2020
This paper deals with two single facility location problems. The first problem is about the deterministic weighted (DW) 1-center of a deterministic tree network (DTN).
A.W. Aboutahoun, F. El-Safty
doaj   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

open access: yesFEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan   +6 more
wiley   +1 more source

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