Results 91 to 100 of about 17,919,985 (298)

ROS‐Responsive Nanoparticle Delivery of Dexmedetomidine Protects the Gut Vascular Barrier After Intestinal Ischemia/Reperfusion via the HDAC‐H3K27ac‐TCF4 Axis

Advanced Science, EarlyView.
A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang, Jian‐Tong Shen, Hua‐Hua Zhang, Si‐Qi Gao, Ji‐Ao Wang, Yue‐Ling Wang, Mei‐Ling Li, Zi‐Meng Liu, Yi‐Nan Zhang, Yan Li, Xu‐Yu Zhang   +10 more
wiley   +1 more source

Smartphone‐Guided Visible Light Modulation of RSNOs for Antimicrobial Activity via Controlled Nitric Oxide Release

Advanced Science, EarlyView.
A light‐activated catheter insert combines antimicrobial blue light with nitric oxide release to generate complementary oxidative and nitrosative stress, producing potent broad‐spectrum antimicrobial activity. The approach achieves greater than 4‐log reductions in bacterial and fungal viability and significantly reduces Staphylococcus aureus ...
Alexander Bruckmann, Adam Brooks Goodman, Myddelton C. Parker, Mark Garren, Ji Eun Park, Chad Schmiedt, Hitesh Handa, Elizabeth J. Brisbois   +7 more
wiley   +1 more source

Bloodstream infection and occlusion of central venous catheters in children

, 2018
One in ten children with a central venous catheter (CVC) develops a central line-associated bloodstream infection (CLABSI),1 which is a life-threatening complication and harmful distraction from time-sensitive treatment. However, across CVC types (figure)
Claire M Rickard, Amanda J Ullman, Rickard, Claire M, Ullman, Amanda J   +3 more
core   +1 more source

Preventing Central Line-Associated Bloodstream Infections (CLABSI)

, 2015
The dominance of central-line-associated bloodstream infection (CLABSI) prevention has become a powerful far-reaching endeavor in recent years. The purpose of this evidence-based practice project is to examine the best practices for preventing central ...
Bernhardt, Courtney
core   +1 more source

Sustained Low Incidence Rates of Central Line-Associated Blood Stream Infections in the Intensive Care Unit

Infection and Drug Resistance, 2021
Waleed A Mazi,1 Mohammed H Abdulwahab,1 Mahmood A Alashqar,1 Yvonne S Aldecoa,1 Zaheda R Bahat,1 Jennifer L Suaking,1 Amir Saeed,2,3 Osama S Yassin,4 Salah Al-Din Mahfouz,5 Abiola Senok6 1Infection Prevention and Control, King Faisal Medical Complex ...
Mazi WA, Abdulwahab MH, Alashqar MA, Aldecoa YS, Bahat ZR, Suaking JL, Saeed A, Yassin OS, Mahfouz SA, Senok A   +9 more
doaj  

Autonomous AI‐Driven Design for Skin Product Formulations

Advanced Intelligent Discovery, EarlyView.
This review presents a comprehensive closed‐loop framework for autonomous skin product formulation design. By integrating artificial intelligence‐driven experiment selection with automated multi‐tiered assays, the approach shifts development from trial‐and‐error to intelligent optimisation.
Yu Zhang, Yongrui Xiao, Chunlin Chen, Dimitrios Tsaoulidis, Kai Yang, Tao Chen   +5 more
wiley   +1 more source

Risk factors for urinary catheter associated bloodstream infection

, 2015
Objectives: Urinary catheter associated bloodstream infection (UCABSI) causes significant morbidity, mortality and healthcare costs. We aimed to define the risk factors for UCABSI.
Playford, EG, Dyer, J, McDougall, DAJ, Bursle, EC, Looke, DFM, Paterson, DL   +5 more
core   +1 more source

Improving central line-associated bloodstream infection prevention bundle compliance to reduce infection rates in a pediatric cardiac intensive care unit. [PDF]

, 2023
Background: Central line-associated bloodstream infection (CLABSI) is the most common healthcare-acquired infection in pediatrics. A pediatric acute care facility in Kentucky created a specialized care team in an effort to track CLABSI bundle compliance ...
Croghan, Aubree
core   +1 more source

SUSTAINED REDUCTION OF CENTRAL LINE–ASSOCIATED PRIMARY BLOODSTREAM INFECTION: IS IT ACHIEVABLE?

Brazilian Journal of Infectious Diseases
Introduction: Central venous catheter–associated bloodstream infection (CLABSI) is a frequent complication in hospitalized patients, associated with increased morbidity, mortality, and costs.
Beatriz Aparecida Silva Cunha, Aline Aparecida de Souza, Vitor Pereira Alves Martins   +2 more
doaj   +1 more source

Appropriate duration of peripherally inserted central catheter maintenance to prevent central line-associated bloodstream infection.

PLoS ONE, 2020
Background/aimProlonged maintenance of central venous catheters, including peripherally inserted central catheters (PICCs), is a major risk factor for central line-associated bloodstream infection (CLABSI).
Seonghun Park, Shinje Moon, Hyunjoo Pai, Bongyoung Kim   +3 more
doaj   +1 more source