Results 71 to 80 of about 17,919,985 (298)

Clinico-Epidemiological Profile of Central Line-Associated Blood Stream Infections and Associated Morbidities among Patients in a Tertiary Care Hospital, Bangalore

National Journal of Community Medicine, 2017
Background: Central line-associated bloodstream infection (CLABSI) is often a complication of the presence of indwelling medical devices. These Central line catheters provide long-term venous access for treatment, delivery of medications and blood ...
K S Sarala, BS Nanda Kumar, V Narendranath   +2 more
doaj  

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Hospital-acquired, laboratory-confirmed bloodstream infection: increased hospital stay and direct costs. [PDF]

, 2002
OBJECTIVES: To determine increased hospital stay and direct costs attributable to hospital-acquired, laboratory-confirmed bloodstream infection (BSI), and to evaluate the matching variable length of stay (LOS).
NOAH N., Noah, Norman, Orsi, Giovanni Battista, DI STEFANO L., Di Stefano, Lidia   +4 more
core   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

A prospective Study on Incidence, Etiology, and Antimicrobial Susceptibility Pattern of Central Line-associated Bloodstream Infection Causing Isolates in a Tertiary Care Institute in North-western India

Medical Journal of Dr. D.Y. Patil Vidyapeeth
Background: One of the most prevalent types of healthcare-associated infections is central line-associated bloodstream infection (CLABSI), which occurs when pathogens enter the bloodstream through a central venous catheter.
Chinkle Sharma, Kriti Goyal, Ekadashi Rajni   +2 more
doaj   +1 more source

Artificial Intelligence‐Empowered Single‐Cell Phenotyping for Rapid, Automated Pathogen Diagnostics

Advanced Science, EarlyView.
This work presents an integrated diagnostic platform that combines microfluidic single‐cell bacterial detection with artificial intelligence‐driven analysis for rapid antimicrobial susceptibility testing. Single‐cell phenotyping enables assessment of antibiotic response in only a few cell replication cycles, while AI analysis supports precise bacterial
Sabita Khadka, Bushra Raahat, Spyros Tragoudas, Hui Li   +3 more
wiley   +1 more source

A Model to Predict Central-Line–Associated Bloodstream Infection Among Patients With Peripherally Inserted Central Catheters: The MPC Score

, 2017
BACKGROUNDPeripherally inserted central catheters (PICCs) are associated with central-line–associated bloodstream infections (CLABSIs). However, no tools to predict risk of PICC-CLABSI have been developed.OBJECTIVETo operationalize or prioritize CLABSI ...
Erica Herc, Flanders, SA, Chopra, V, Washer, LL, Conlon, A, Payal Patel, Laraine L. Washer, Anna Conlon, Vineet Chopra, Herc, E, Scott A. Flanders, Patel, P   +11 more
core   +1 more source

Using interprofessional collaboration to reduce reported rates of central-line-associated bloodstream infection in an intensive care setting. [PDF]

Infect Control Hosp Epidemiol
Using a multicomponent approach that included blood-culture stewardship, evaluation for secondary sources of bloodstream infection, improved documentation, and prompt central-line removal, an interprofessional team improved patient care and reduced ...
Musgrove H, Ruby A, Chami E, Pollak E, Suleyman G, Gupta A.   +5 more
europepmc   +3 more sources

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

Epidemiology and Clinical Insights of Catheter-Related Candidemia in Non-ICU Patients with Vascular Access Devices

Microorganisms
Introduction: Vascular access devices (VADs), namely peripheral VADs (PVADs) and central venous VADs (CVADs), are crucial in both intensive care unit (ICU) and non-ICU settings.
Giovanni Scaglione, Marta Colaneri, Martina Offer, Lucia Galli, Fabio Borgonovo, Camilla Genovese, Rebecca Fattore, Monica Schiavini, Alba Taino, Maria Calloni, Francesco Casella, Antonio Gidaro, Federico Fassio, Valentina Breschi, Jessica Leoni, Chiara Cogliati, Andrea Gori, Antonella Foschi   +17 more
doaj   +1 more source