Results 111 to 120 of about 16,200,897 (373)

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

open access: yesFEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang   +2 more
wiley   +1 more source

A stepwise emergence of evolution in the RNA world

open access: yesFEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Prognosis of Early Stage Cervical Cancer According to Patterns of Recurrence

open access: yesCancer Management and Research, 2021
Yuanyuan Chen,1,2 Yiming Zhu,3 Jinchang Wu1 1Department of Radiation, The Affiliated Suzhou Hospital of Nanjing Medical University and Second Affiliated Hospital of Xuzhou Medical University, Suzhou, Jiangsu, People’s Republic of China; 2Department of ...
Chen Y, Zhu Y, Wu J
doaj  

Flow‐based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product

open access: yesMolecular Oncology, EarlyView.
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens   +8 more
wiley   +1 more source

Health and Poverty Alleviation as Central to the Vision of a Developed India by 2047

open access: yesJournal of Public Health and Primary Care
The importance of living a healthy life has never been lost to us in India. Historically, India has equated a healthy mind with a healthy body as central to fulfillment of a purposeful life. Therefore, it is only pertinent that health retains its central
Sunil Kumar Raina
doaj   +1 more source

Completely Centrally Essential Rings [PDF]

open access: yesarXiv
A ring $R$ is said to be centrally essential if for every its non-zero element $a$, there exist non-zero central elements $x$ and $y$ with $ax = y$. A ring $R$ is said to be completely centrally essential if all its factor rings are centrally essential rings.
arxiv  

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

open access: yesMolecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever   +1 more
wiley   +1 more source

Challenges related to the implementation of the CCMDD programme in Sekhukhune clinics

open access: yesHealth SA Gesondheid: Journal of Interdisciplinary Health Sciences
Background: Implementation of the central chronic medicines dispensing and distribution (CCMDD) programme in most of Sekhukhune primary health care (PHC) has been challenging.
Ragosebo P. Sekopa   +1 more
doaj   +1 more source

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