Results 251 to 260 of about 3,146,543 (345)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Process-Informed Subsampling Improves Subseasonal Rainfall Forecasts in Central America. [PDF]

Geophys Res Lett
Kowal KM, Slater LJ, Li S, Kelder T, Hall KJC, Moulds S, García-López AA, Birkel C.   +7 more
europepmc   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

"Despartares Decoloniales": The Implications of "Territorio Cuerpo-Tierra" for Studying Women's Embodied Resilience to Trauma in El Salvador, Central America. [PDF]

Violence Against Women
Liegghio M, Ordóñez Sánchez SG.
europepmc   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Multiple sclerosis in Central America and Caribbean countries: frequency and clinical characterization of an emergent disease. [PDF]

Front Epidemiol
Gracia F, Ramírez Navarro DA, Ramírez Sánchez NE, Weiser R, Parajeles-Vindas A, Portillo Rivera LI, Torres EL, García Valle LA, Sanabria-Castro A, Abdón López C, Araujo P, Ayerdis Zamora MJ, Balmaceda-Meza A, Benzadon Cohen A, Candelario Cueto A, Castillo D, Castro-Escobar R, Corea Urbina KZ, de Peña Rivas A, Sotelo OD, Enamorado Claros T, Giroud Benítez JL, Gracia K, Larreategui M, Martínez Cerrato JA, Medina Báez JP, Menjivar Samayoa CE, Miranda-Loria G, Monterrey-Alvarez P, Morales Arguello LA, Ortiz M, Pérez Baldioceda CD, Pinilla Aguilar L, Salinas LCR, Rodríguez-Moreno V, Rojas-Chaves S, Román-Garita N, Santos Pujols B, Valderrama C, Van Sijtveld I, Zabala Angeles I, Rivera VM, Armien B.   +42 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Molecular Detection of <i>Leishmania</i> (<i>V.</i>) <i>braziliensis</i> and <i>Leishmania</i> (<i>M.</i>) <i>martiniquensis</i> Infecting Domestic Animals from Panama, Central America. [PDF]

Animals (Basel)
Pineda V, Calzada JE, Montilla S, Rodríguez I, Howard E, Torres AI, Vasquez V, Reina A, Saldaña A, González K.   +9 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Analysis of Injury Epidemiology in Soccer Players in the 2019 Confederation of North, Central America and Caribbean Association Football Gold Cup as Reported by Team Physicians. [PDF]

Arthrosc Sports Med Rehabil
Forsythe B, Knapik DM, Khazi-Syed D, Chang J, Bohn C, Hand C, Korrapati A, Lavoie-Gagne O, Chiampas G, Mandelbaum BR, Chahla J.   +10 more
europepmc   +1 more source