Results 261 to 270 of about 3,146,543 (345)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Integration of Dementia Systems in Central America: A Social Network Approach. [PDF]

Int J Integr Care
Curreri NA, Griffiths D, Mccabe L.
europepmc   +1 more source

The Central American Free Trade Agreement: Free Trade or Do Women Pay the Price?

, 2005
Andrea Hunwick
openalex   +1 more source

Thermochronology, geochronology and geochemistry of the Western and Central cordilleras and Sierra Nevada de Santa Marta, Colombia: the tectonic evolution of NW South America

, 2010
Diego Villagómez Díaz
openalex   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Deep cryptic diversity in the <i>Craugastor podiciferus</i> Species Group (Anura: Craugastoridae) of Isthmian Central America revealed by mitochondrial and nuclear data. [PDF]

PeerJ
Arias E, Crawford AJ, Hertz A, Parra Olea G.   +3 more
europepmc   +1 more source

Seabirds in the Gulf of Fonseca, Pacific Central America, during El Nino 2015/16

, 2018
John van Dort
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Admixture Mapping of Chronic Kidney Disease and Risk Factors in Hispanic/Latino Individuals From Central America Country of Origin. [PDF]

Circ Genom Precis Med
Horimoto ARVR, Sun Q, Lash JP, Daviglus ML, Cai J, Haack K, Cole SA, Thornton TA, Browning SR, Franceschini N.   +9 more
europepmc   +1 more source