Results 301 to 310 of about 2,116,934 (358)

Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia

Advanced Science, EarlyView.
Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen, Jiale Wei, Shibing Tang, Dongliang Wu, Liangyi Zong, Shuyuan Ma, Qing Xiong, Ruijie Gong, Siyuan Xu, Chuxuan Peng, Qin Feng, Songchen Liu, Qitong Liu, Yuhua Ye, Quan Zhao, Cheng Luo, Peng Huang, Zhihai Li, Xiangqian Kong, Xianjiang Lan   +19 more
wiley   +1 more source

Private health insurance in Gulf Cooperation Council countries: A scoping review. [PDF]

Health Policy Open
Reka H, van Kessel R, Mossialos E, Groot W, Pavlova M.   +4 more
europepmc   +1 more source

A Conjugation Delivery System of Macrophages and Platelet Pharmacytes Promotes Regeneration After Spinal Cord Injury

Advanced Science, EarlyView.
A macrophage–platelet conjugation system (M‐P‐NPs@PPARγ) targets injure tissue to co‐deliver platelet mitochondria and PPARγ‐encoding NPs. This strategy boosts the macrophage energy supply and restores lipid homeostasis, leading to synergistically enhanced efferocytosis and tissue repair Abstract Mitochondrial dysfunction occurs in macrophages with ...
Haoli Wang, Hao Hu, Yijun Li, Lintao Hu, Chenhui Gu, Yiwei Zhu, Jing Huang, Na Li, Shuqi Jiang, Shouyan Zu, Jiachen Xu, Yining Wang, Ke Yang, Pengfei Chen, Liqing Shangguan, Yongcheng Wang, Shunwu Fan, Xianfeng Lin, Qingqing Wang   +18 more
wiley   +1 more source

Correction: Impact of nutrition and health interventions on undernutrition: an overview of systematic reviews. [PDF]

Int J Equity Health
Vilar-Compte M, Rovelo-Velázquez N, Nguyen HTM, Mehta MA.   +3 more
europepmc   +1 more source

Correction: Surgical care bundle: effect on post-caesarean wound infection. [PDF]

BMC Womens Health
Nouh FM, Abualruz H, Mohamed RF, Yousef AA, Hrinat JA, Hendi AG, Ashour ESS, Alzoubi M, Rahbeni TA, Al-Mugheed K, Abdelaliem SMF.   +10 more
europepmc   +1 more source

Rheotactic Responses in <i>Bufo bufo</i> Tadpoles-Insights Into Adaptation to Lotic Environment. [PDF]

Ecol Evol
Török-Oance M, Török-Oance R.
europepmc   +1 more source

The global economic burden of cirrhosis and other chronic liver diseases: A health-augmented macroeconomic modeling study. [PDF]

Hepatol Commun
Zhang R, Li J, Gong Y, Mu K, Zheng J, Yin X.   +5 more
europepmc   +1 more source

The evolution of the global disease burden of polycystic ovary syndrome and the role of regional heterogeneity in high body mass index exposure: a spatiotemporal analysis based on the global burden of disease 2021. [PDF]

Front Reprod Health
Feng Y, Wu L, Liu J, Feng Y.
europepmc   +1 more source

A independência do Banco Central: uma análise comparativa entre as visões de Rogoff e Walsh The Central Bank independence: a comparative analysis of the arguments of Rogoff and Walsh

, 1999
Hélder Ferreira de Mendonça
openalex   +1 more source